| 货号 | K151QWG-4 |
| 描述 | Human tumor necrosis factor alpha (TNF-α), also known as tumor necrosis factor ligand superfamily member 2 (TNFSF2) and cachectin, is a 25.6 kDa cytokine. TNF is a transmembrane protein that oligomerizes intracellularly to form a non-covalent homotrimer. The membrane-bound soluble portion of the homotrimer is cleaved by TACE/ADAM17 to form TNF-α. The homotrimer binds to the receptors TNF RI and TNF RII, both of which are also expressed as homotrimers. TNF-α is mainly secreted by macrophages and can induce apoptosis in some tumor cell lines. It stimulates IL-1, which induces cachexia and causes fever. The intracellular form of TNF induces IL-12 production in dendritic cells. It can induce sepsis and inflammation and can inhibit tumorigenesis and viral replication. The Human TNF-α Kit provides assay-specific components for the quantitative determination of endogenous TNF-α in human urine, serum, plasma, and cell culture supernatants. |
| 反应种属 | Human |
| 应用 | Cytokines & Chemokines,Immunology/Inflammation |
| 说明书 | Proinflammatory Panel 1 human Calibrator Insert Proinflammatory Panel 1 human Control Insert Proinflammatory Panel 1 human Insert |
| 供应商 | MSD |
| 样本类型以及上样量 | Serum, Plasma, Urine, Cell Culture Supernatant |
| 灵敏度 | 0.04 pg/mL |
| 检测范围 | 0.04–248 pg/mL |
| 存放说明 | Multi-Component |
| 产品用途 | For Research Use Only. Not for use in diagnostic procedures. |