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货号： bs-5743R 基本售价： 1380.0 元 规格： 100ul
- 规格：100ul
- 价格：1380.00元
- 规格：200ul
- 价格：2200.00元
产品信息
- 产品编号
- bs-5743R
- 英文名称
- CDKN3
- 中文名称
- 细胞周期蛋白依赖性激酶抑制蛋白3抗体
- 别 名
- Cdk associated protein phosphatase; CDI1; CDK2 associated dual specificity phosphatase; CIP2; Cyclin dependent kinase inhibitor 3; Cyclin dependent kinase interactor 1; Cyclin dependent kinase-interacting protein 2; KAP1; Kinase associated phosphatase.
- 规格价格
- 100ul/1380元购买 200ul/2200元购买 大包装/询价
- 说 明 书
- 100ul 200ul
- 研究领域
- 肿瘤 细胞生物 免疫学 细胞周期蛋白 激酶和磷酸酶
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Sheep,
- 产品应用
- WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 24kDa
- 细胞定位
- 细胞浆
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human CDKN3:51-150/212
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- PubMed
- PubMed
- 产品介绍
- background:
CDKN3 is a second dual specificity phosphatase that interacts with cyclin dependent kinases.The ability of CDKN3 to bind multiple cyclin-dependent kinases suggests that it may be a critical control element in cell cycle regulation, presumably by regulating the phosphorylation state of a Cdk or Cdk-associated protein.
Function:
May play a role in cell cycle regulation. Dual specificity phosphatase active toward substrates containing either phosphotyrosine or phosphoserine residues. Dephosphorylates CDK2 at Thr-160 in a cyclin-dependent manner.
Subunit:
Interacts with cyclin-dependent kinases such as CDK1, CDK2 and CDK3. Does not interact with CDK4. Interacts (via C-terminus) with phosphorylated CDK2 (via C-terminal helix). Interacts with MS4A3 (via C-terminus); the interaction enhances CDKN3 enzymatic activity.
Subcellular Location:
Cytoplasm, perinuclear region.
DISEASE:
Defects in CDKN3 are found in patients with hepatocellular carcinoma (HCC) [MIM:114550].
Similarity:
Belongs to the protein-tyrosine phosphatase family.
SWISS:
Q16667
Gene ID:
1033
Database links:Entrez Gene: 1033 Human
Entrez Gene: 72391 Mouse
Entrez Gene: 397589 Pig
Entrez Gene: 289993 Rat
Omim: 123832 Human
SwissProt: Q16667 Human
SwissProt: Q810P3 Mouse
SwissProt: Q9MYN5 Pig
SwissProt: B2RZ50 Rat
Unigene: 84113 Human
Unigene: 272394 Mouse
Unigene: 107220 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.