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货号： bs-7033R-AP 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-7033R-AP
- 英文名称
- Anti-EphA6/AP
- 中文名称
- 碱性磷酸酶（AP）标记的酪氨酸蛋白激酶受体A6抗体
- 别 名
- Ehk 2; Ehk2; EPH homology kinase 2; Eph Receptor A6; EphA6; ephrin receptor EphA6; ephrin type A receptor 6; Hek12; EPHA6_HUMAN.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 心血管 神经生物学 信号转导 激酶和磷酸酶 细胞类型标志物
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep,
- 产品应用
- WB=1:50-200 IHC-P=1:50-200 IHC-F=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 114kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human EphA6/Eph receptor A6
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
The Eph family of receptors comprises the largest known family of receptor tyrosine kinases. Ligands of Eph family receptors are structurally related membrane bound proteins that can be subdivided into two major subclasses, ephrin A and ephrin B. Expression of Eph receptors is tissue specific and appears to be tied to developmental events. Ligands in the ephrin A subclass, including the prototype family member ephrin A1 (B61), are membrane associated through glycosylphosphatidyl inositol linkages, whereas ephrin B subclass consists of ligands with transmembrane domains. The general role of the Eph family is in mediating repulsive cell-cell interaction.
Function:
Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling (By similarity).
Subunit:
Heterotetramer upon binding of the ligand. The heterotetramer is composed of an ephrin dimer and a receptor dimer. Oligomerization is probably required to induce biological responses (By similarity).
Subcellular Location:
Membrane; Single-pass type I membrane protein (By similarity).
Tissue Specificity:
Expressed in brain and testis.
Similarity:
Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily.
Contains 2 fibronectin type-III domains.
Contains 1 protein kinase domain.
Contains 1 SAM (sterile alpha motif) domain.
Database links:
UniProtKB/Swiss-Prot: Q9UF33.2
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.