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货号： bs-7062R-AP 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-7062R-AP
- 英文名称
- Anti-DEDD1/AP
- 中文名称
- 碱性磷酸酶（AP）标记的死亡效应结构域蛋白1抗体
- 别 名
- CASP8IP1; Death effector domain containing; Death effector domain containing protein; Death effector domain containing testicular molecule; DEDD 1; DEDD1; DEDPro 1; DEDPro1; DEFT; FLDED 1; FLDED1; KE 05; KE05; OTTHUMP00000031822.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 肿瘤 细胞生物 细胞凋亡
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Chicken, Pig, Cow,
- 产品应用
- WB=1:50-200 IHC-P=1:50-200 IHC-F=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 35kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human DEDD1
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
This gene encodes a protein that contains a death effector domain (DED). DED is a protein-protein interaction domain shared by adaptors, regulators and executors of the programmed cell death pathway. Overexpression of this gene was shown to induce weak apoptosis. Upon stimulation, this protein was found to translocate from cytoplasm to nucleus and colocalize with UBTF, a basal factor required for RNA polymerase I transcription, in the nucleolus. At least three transcript variants encoding the same protein have been found for this gene.
Function:
A scaffold protein that directs CASP3 to certain substrates and facilitates their ordered degradation during apoptosis. May also play a role in mediating CASP3 cleavage of KRT18. Regulates degradation of intermediate filaments during apoptosis. May play a role in the general transcription machinery in the nucleus and might be an important regulator of the activity of GTF3C3. Inhibits DNA transcription in vitro.
Subunit:
Interacts with CASP8, CASP10, KRT8, KRT18, CASP3 and FADD. Homodimerizes and heterodimerizes with DEDD2.
Subcellular Location:
Cytoplasm. Nucleus, nucleolus.
Tissue Specificity:
Widely expressed with highest levels in testis.
Post-translational modifications:
Exists predominantly in a mono- or diubiquitinated form.
Similarity:
Contains 1 DED (death effector) domain.
Database links:Entrez Gene: 9191 Human
Entrez Gene: 21945 Mouse
Entrez Gene: 83631 Rat
Omim: 606841 Human
SwissProt: O75618 Human
SwissProt: Q9Z1L3 Mouse
SwissProt: Q9Z2K0 Rat
Unigene: 146406 Human
Unigene: 270139 Mouse
Unigene: 203286 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.