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货号： bs-6843R-AP 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-6843R-AP
- 英文名称
- Anti-MAGED1/AP
- 中文名称
- 碱性磷酸酶（AP）标记的黑色素瘤相关抗原D1抗体
- 别 名
- DLXIN 1; MAGD1_HUMAN; MAGE D1 antigen; MAGE tumor antigen CCF; MAGE-D1 antigen; Maged1; Melanoma antigen family D 1; Melanoma associated antigen D1; Melanoma-associated antigen D1; Neurotrophin receptor interacting MAGE homolog; Neurotrophin receptor-interacting MAGE homolog; NRAGE; PP2250.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 肿瘤 细胞生物 免疫学 细胞凋亡
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat,
- 产品应用
- WB=1:50-200 IHC-P=1:50-200 IHC-F=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 85kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human MAGED1
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
Involved in the apoptotic response after nerve growth factor (NGF) binding in neuronal cells. Binds p75NTR and antagonizes its association with TrkA, inhibits cell cycle progression, and facilitates p75NTR-mediated apoptosis. May act as a regulator of the function of DLX family members. May regulate p53 transcriptional activity and inhibit cell proliferation. Enhances p53 phosphorylation and accumulation.
Function:
Involved in the apoptotic response after nerve growthfactor (NGF) binding in neuronal cells. Binds NGFR/p75NTR andantagonizes its association with NTRK1/TrkA, inhibits cell cycleprogression, and facilitates NGFR-mediated apoptosis. May act as aregulator of the function of DLX family members. May regulateTP53/p53 transcriptional activity and inhibit cell proliferation.Enhances TP53 phosphorylation and accumulation. May enhanceubiquitin ligase activity of RING-type zinc finger-containing E3ubiquitin-protein ligases. Proposed to act through recruitmentand/or stabilization of the Ubl-conjugating enzyme (E2) at theE3:substrate complex.
Subunit:
Interacts with DLX5, DLX7 and MSX2 and formshomomultimers. Interacts with UNC5A (By similarity). Interacts withthe p75 neurotrophin receptor. Interacts with TRIM28 and PJA1.
Subcellular Location:
Cytoplasm (By similarity). Cell membrane;Peripheral membrane protein (By similarity). Note=Expression shiftsfrom the cytoplasm to the plasma membrane upon stimulation with NGF(By similarity).
Tissue Specificity:
Expressed in bone marrow stromal cells fromboth multiple myeloma patients and healthy donors. Seems to beubiquitously expressed.
Similarity:
Contains 1 MAGE domain.
Database links:Entrez Gene: 9500 Human
Entrez Gene: 94275 Mouse
Entrez Gene: 84469 Rat
Omim: 300224 Human
SwissProt: Q9Y5V3 Human
SwissProt: Q9QYH6 Mouse
SwissProt: Q9ES73 Rat
Unigene: 5258 Human
Unigene: 27578 Mouse
Unigene: 54596 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.