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货号： bs-7672R-AP 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-7672R-AP
- 英文名称
- Anti-NRH2/AP
- 中文名称
- 碱性磷酸酶（AP）标记的死亡结构域蛋白NRH2抗体
- 别 名
- NRADD; PLAIDD; NRADD_RAT; Death domain-containing membrane protein NRADD; Neurotrophin receptor homolog-2; Neurotrophin receptor-alike death domain protein; P75-like apoptosis-inducing death domain protein.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 细胞生物 细胞凋亡
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Mouse, Rat, Dog, Pig, Horse, Sheep,
- 产品应用
- WB=1:50-200 IHC-P=1:50-200 IHC-F=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 24kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from rat NRH2
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
A single transmembrane protein highly expressed in embryonic tissues and involved in inducing apoptosis.
Function:
Modulates NTRK1 signaling. Can activate severalintracellular signaling pathways, leading to activation of JUN.Promotes translocation of SORT1 to the cell membrane, and therebyhinders lysosomal degradation of SOTR1 and promotes its interactionwith NGFR (By similarity). Both isoform 1 and isoform 2 promoteapoptosis.
Subunit:
Interacts with NTRK1. Isoform 1 andisoform 2 interact with NGFR. Interacts with SORT1.
Subcellular Location:
Cell membrane; Single-pass type III membraneprotein. Nucleus (By similarity). Note=Proteolytic processing givesrise to an intracellular domain that translocates to the nucleus.
Tissue Specificity:
Detected in embryo, including embryonic brain.Detected at very low levels in adult testis, spleen, thymus andlung.
Post-translational modifications:
Isoform 1 is N-glycosylated. Isoform 2 is not N-glycosylated.
Similarity:
Contains 1 death domain.
Database links:
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.