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货号： bs-7797R-AP 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-7797R-AP
- 英文名称
- Anti-DUSP13/AP
- 中文名称
- 碱性磷酸酶（AP）标记的双特异性磷酸酶13抗体
- 别 名
- BEDP; Branching enzyme interacting dual specificity protein phosphatase; Dual specificity phosphatase 13; Dual specificity phosphatase SKRP4; DUSP13A; DUSP13B; FLJ32450; MDSP; Muscle restricted dual specificity phosphatase; SKRP4; Testis and skeletal muscle specific DSP; TMDP; DUS13_HUMAN.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 细胞生物 发育生物学 信号转导 细胞周期蛋白 激酶和磷酸酶
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Cow, Sheep,
- 产品应用
- WB=1:50-200 IHC-P=1:50-200 IHC-F=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 22kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human DUSP13
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
Members of the protein-tyrosine phosphatase superfamilycooperate with protein kinases to regulate cell proliferation anddifferentiation. This superfamily is separated into two familiesbased on the substrate that is dephosphorylated. One family, thedual specificity phosphatases (DSPs) acts on both phosphotyrosineand phosphoserine/threonine residues. This gene encodes differentbut related DSP proteins through the use of non-overlapping openreading frames, alternate splicing, and presumed differenttranscription promoters. Expression of the distinct proteins fromthis gene has been found to be tissue specific and the proteins maybe involved in postnatal development of specific tissues. A proteinencoded by the upstream ORF was found in skeletal muscle, whereasthe encoded protein from the downstream ORF was found only intestis. In mouse, a similar pattern of expression was found.Multiple alternatively spliced transcript variants were described,but the full-length sequence of only some were determined.[provided by RefSeq, Jul 2008].
Function:
May be involved in the regulation of meiosis and/ordifferentiation of testicular germ cells during spermatogenesis.Exhibits intrinsic phosphatase activity towards bothphospho-seryl/threonyl and -tyrosyl residues of myelin basicprotein, with similar specific activities in vitro.
Tissue Specificity:
Most abundantly expressed in the testis. Alsofound in the skeletal muscle. Testis-specific (at protein level).
Similarity:
Belongs to the protein-tyrosine phosphatase family.Non-receptor class dual specificity subfamily.
Contains 1 tyrosine-protein phosphatase domain.
Database links:
UniProtKB/Swiss-Prot: Q9UII6.3
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.