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货号： bs-7963R-AP 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-7963R-AP
- 英文名称
- Anti-ANKRD13A/AP
- 中文名称
- 碱性磷酸酶（AP）标记的锚蛋白重复结构域蛋白13A抗体
- 别 名
- ANKRD13; ANKRD13A ankyrin repeat domain 13A; ANKRD13A; Ankyrin repeat domain 13; Protein KE03; AN13A_HUMAN.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 细胞生物 免疫学
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Cow, Rabbit, Sheep,
- 产品应用
- WB=1:50-200 IHC-P=1:50-200 IHC-F=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 68kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human ANKRD13A
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- Function:
Ubiquitin-binding protein that specifically recognizes and binds Lys-63-linked ubiquitin. Does not bind Lys-48-linked ubiquitin. Positively regulates the internalization of ligand-activated EGFR by binding to the Ub moiety of ubiquitinated EGFR at the cell membrane.
Subunit:
Interacts (via the UIM 3 and 4 repeats) with EGFRc(ubiquitinated); the interaction is direct, inhibited by ANKRD13A monoubiquitination and may regulate EGFR internalization.
Subcellular Location:
Cell membrane. Late endosome. Note=Interaction with EGFR may enhance association with the cell membrane.
Post-translational modifications:
Monoubiquitinated, inhibits interaction with ubiquitinated EGFR.
Similarity:
Contains 2 ANK repeats.
Contains 3 UIM (ubiquitin-interacting motif) repeats.
Database links:Entrez Gene: 88455Human
Entrez Gene: 68420Mouse
SwissProt: Q8IZ07Human
SwissProt: Q80UP5Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.