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货号： bs-8291R-AP 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-8291R-AP
- 英文名称
- Anti-DPY19L2/AP
- 中文名称
- 碱性磷酸酶（AP）标记的DPY19L2蛋白抗体
- 别 名
- D19L2_HUMAN; dpy 19 like 2; dpy 19 like 2 (C. elegans); Dpy 19 like protein 2; Dpy-19-like protein 2; dpy19; DPY19L2; FLJ32949; FLJ36166; Protein dpy 19 homolog 2; Protein dpy-19 homolog 2.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 细胞生物 免疫学 发育生物学
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Dog, Pig, Cow,
- 产品应用
- WB=1:50-200 IHC-P=1:50-200 IHC-F=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 87kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human DPY19L2
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
Required during spermatogenesis for sperm head elongation and acrosome formation.
Function:
Required during spermatogenesis for sperm head elongation and acrosome formation.
Subunit:
Membrane; Multi-pass membrane protein (Potential).
Subcellular Location:
Involvement in disease：Defects in DPY19L2 are a cause of globozoospermia (GLOBZOOS) . An infertility disorder caused by spermatogenesis defects. The most prominent feature is the malformation of the acrosome. In the most severe cases the acrosome is totally absent. Globozoospermia is also characterized by abnormal nuclear shape as well as abnormal arrangement of the mitochondria of the spermatozoon. Note=Deletions in DPY19L2 are probably the major cause of GLOBZOOS.
Tissue Specificity:
Widely expressed with high expression in testis.
DISEASE:
Defects in DPY19L2 are the cause of spermatogenic failure type 9 (SPGF9) [MIM:613958]. An infertility disorder caused by spermatogenesis defects. The most prominent feature is the malformation of the acrosome, which can be totally absent in most severe cases. Additional features are an abnormal nuclear shape and abnormal arrangement of the mitochondria of the spermatozoon. Note=Deletions in DPY19L2 are probably the major cause of SPGF9.
Similarity:
Belongs to the dpy-19 family.
Database links:
UniProtKB/Swiss-Prot: Q6NUT2.2
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.