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货号： bs-8327R-AP 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-8327R-AP
- 英文名称
- Anti-SLU7/AP
- 中文名称
- 碱性磷酸酶（AP）标记的SLU7蛋白抗体
- 别 名
- 9G8; hSlu7; MGC9280; Pre mRNA splicing factor SLU7; Pre-mRNA-splicing factor slu7; SLU 7; SLU-7; slu7; SLU7 splicing factor homolog (S. cerevisiae); SLU7 splicing factor homolog; SLU7_HUMAN; Step II splicing factor SLU7; Zinc knuckle motif containing.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 细胞生物 免疫学 信号转导 表观遗传学
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit,
- 产品应用
- WB=1:50-200 IHC-P=1:50-200 IHC-F=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 68kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human SLU7
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
Participates in the second catalytic step of pre-mRNA splicing, when the free hydroxyl group of exon I attacks the 3-splice site to generate spliced mRNA and the excised lariat intron. Required for holding exon 1 properly in the spliceosome and for correct AG identification when more than one possible AG exists in 3-splicing site region. May be involved in the activation of proximal AG. Probably also involved in alternative splicing regulation.
Function:
Participates in the second catalytic step of pre-mRNA splicing, when the free hydroxyl group of exon I attacks the 3-splice site to generate spliced mRNA and the excised lariat intron. Required for holding exon 1 properly in the spliceosome and for correct AG identification when more than one possible AG exists in 3-splicing site region. May be involved in the activation of proximal AG. Probably also involved in alternative splicing regulation.
Subunit:
Component of late spliceosomal complexes. Associates with the spliceosome prior to recognition of the 3-splice site for step II, probably during catalysis of step I.
Subcellular Location:
Nucleus. Cytoplasm. Predominantly nuclear. Shuttling between the nucleus and the cytoplasm is regulated by the CCHC-type zinc finger. Upon UV-C stress stimulus, the nuclear concentration of the protein decreases, affecting alternative splicing.
Similarity:
Belongs to the SLU7 family.
Database links:
UniProtKB/Swiss-Prot: O95391.2
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.