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货号： bs-8373R-AP 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-8373R-AP
- 英文名称
- Anti-UBE2E1/AP
- 中文名称
- 碱性磷酸酶（AP）标记的泛素蛋白连接酶E1抗体
- 别 名
- UB2E1_HUMAN; UbcH6; UBE2E1; Ubiquitin carrier protein E1; Ubiquitin-conjugating enzyme E2 E1; Ubiquitin-protein ligase E1.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Mouse, Rat, Chicken, Pig, Cow, Sheep,
- 产品应用
- WB=1:50-200 IHC-P=1:50-200 IHC-F=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 21kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human UBCH6/UBE2E1
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
The ubiquitin (Ub) pathway involves three sequential enzymatic steps that facilitate the conjugation of Ub and Ub-like molecules to specific protein substrates. The first step requires the ATP-dependent activation of the Ub C-terminus and the assembly of multi-Ub chains by the Ub-activating enzyme known as the E1 component. The Ub chain is then conjugated to the Ub-conjugating enzyme (E2) to generate an intermediate Ub-E2 complex. The Ub-ligase (E3) then catalyzes the transfer of Ub from E2 to the appropriate protein substrate. UBE2E1 and UBE2L3, also designated UBCH6 and UBCH7 respectively in human, are E2 conjugating enzymes that interact with various proteins. Specifically, UBE2E1 interacts with the tumor suppressor protein TSSC5. UBE2L3 has been shown to mediate c-fos degradation, NF-kB maturation, human papilloma virus-mediated p53 and Myc protein degradation.
Function:
Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Catalyzes the covalent attachment of ISG15 to other proteins. Mediates the selective degradation of short-lived and abnormal proteins. In vitro also catalyzes Lys-48-linked polyubiquitination.
Subunit:
Interacts with RNF14.
Subcellular Location:
Nucleus.
Post-translational modifications:
ISGylation suppresses ubiquitin E2 enzyme activity.
Similarity:
Belongs to the ubiquitin-conjugating enzyme family.
Database links:Entrez Gene: 7324 Human
Entrez Gene: 22194 Mouse
Omim: 602916 Human
SwissProt: P51965 Human
SwissProt: P52482 Mouse
SwissProt: Q541Z5 Mouse
Unigene: 164853 Human
Unigene: 4429 Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.