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货号： bs-9045R-AP 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-9045R-AP
- 英文名称
- Anti-TRPM8/AP
- 中文名称
- 碱性磷酸酶（AP）标记的“冷”蛋白TRPM8抗体
- 别 名
- LTrpC-6; LTrpC6 antibody Short form of the TRPM8 cationic channel; Transient receptor potential cation channel subfamily M member 8; Transient receptor potential p8; Trp p8; Trp-p8; Trpm8; TRPM8_HUMAN; TRPP8; MGC2849; transient receptor potential-p8; Long transient receptor potential channel 6.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 肿瘤 细胞生物 免疫学 神经生物学 信号转导
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Dog, Sheep,
- 产品应用
- IHC-P=1:50-200 IHC-F=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 128kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human TRPM8
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
Receptor-activated non-selective cation channel involved in detection of sensations such as coolness, by being activated by cold temperature below 25 degrees Celsius. Activated by icilin, eucalyptol, menthol, cold and modulation of intracellular pH. Involved in menthol sensation. Permeable for monovalent cations sodium, potassium, and cesium and divalent cation calcium. Temperature sensing is tightly linked to voltage-dependent gating. Activated upon depolarization, changes in temperature resulting in graded shifts of its voltage-dependent activation curves. The chemical agonists menthol functions as a gating modifier, shifting activation curves towards physiological membrane potentials. Temperature sensitivity arises from a tenfold difference in the activation energies associated with voltage-dependent opening and closing.
Function:
Receptor-activated non-selective cation channel involved in detection of sensations such as coolness, by being activated by cold temperature below 25 degrees Celsius. Activated by icilin, eucalyptol, menthol, cold and modulation of intracellular pH. Involved in menthol sensation. Permeable for monovalent cations sodium, potassium, and cesium and divalent cation calcium. Temperature sensing is tightly linked to voltage-dependent gating. Activated upon depolarization, changes in temperature resulting in graded shifts of its voltage-dependent activation curves. The chemical agonists menthol functions as a gating modifier, shifting activation curves towards physiological membrane potentials. Temperature sensitivity arises from a tenfold difference in the activation energies associated with voltage-dependent opening and closing.
Subunit:
Homotetramer (By similarity).
Subcellular Location:
Membrane; Multi-pass membrane protein (Probable).
Tissue Specificity:
Expressed in prostate. Also expressed in most in prostate tumors. Also expressed in non-prostatic primary tumors such as colon, lung, breast and skin tumors.
Similarity:
Belongs to the transient receptor (TC 1.A.4) family. LTrpC subfamily. TRPM8 ub-subfamily.
Database links:Entrez Gene: 79054Human
Entrez Gene: 171382Mouse
Entrez Gene: 171384Rat
Omim: 606678Human
SwissProt: Q7Z2W7Human
SwissProt: Q8R4D5Mouse
SwissProt: Q8R455Rat
Unigene: 366053Human
Unigene: 218753Mouse
Unigene: 81225Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
TRPM8与感应热和辣的蛋白质属于同一家族，它存在于特定神经细胞的细胞膜上，成为响应外界信号的开关通道。科学家研究发现，当温度低于27摄氏度或者醇存在的条件下，TRPM8通道都会打开，使钙离子等带正电的粒子进入细胞。TRPM8的蛋白质在产生冷知觉的过程中起着主导作用，并且控制着低温对机体疼痛的缓解效果,TRPM8故称是“冷”蛋白。