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货号： bs-9805R-AP 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-9805R-AP
- 英文名称
- Anti-C2orf18/AP
- 中文名称
- 碱性磷酸酶（AP）标记的2号染色体开放阅读框18抗体
- 别 名
- ANT2 binding protein; ANT2BP; Chromosome 2 open reading frame 18; FLJ20555; S35F6_HUMAN.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 肿瘤 细胞生物 免疫学 结合蛋白 线粒体
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Pig, Cow, Horse, Rabbit, Sheep,
- 产品应用
- WB=1:50-200 IHC-P=1:50-200 IHC-F=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 38kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human C2orf18/ANT2BP
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 癈 for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20癈. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 癈.
- 产品介绍
- background:
C2orf18 is a 371 amino acid multi-pass membrane protein that contains one DUF6 domain and is encoded by a gene that maps to human chromosome 2p23.3. As the second largest human chromosome, chromosome 2 makes up approximately 8% of the human genome and contains 237 million bases encoding over 1,400 genes. A number of genetic diseases are linked to genes on chromosome 2. Harlequin icthyosis, a rare skin deformity, is associated with mutations in the ABCA12 gene. The lipid metabolic disorder sitosterolemia is associated with ABCG5 and ABCG8. An extremely rare recessive genetic disorder, Alstr鰉 syndrome, is related to mutations in the ALMS1 gene. Chromosome 2 contains a probable vestigial second centromere as well as vestigial telomeres, which gives credence to the hypothesis that human chromosome 2 formed as a result of an ancient fusion of two ancestral chromosomes, which are still present in modern day apes.
Function:
Involved in the maintenance of mitochondrial membrane potential in pancreatic ductal adenocarcinoma (PDAC) cells. Promotes pancreatic ductal adenocarcinoma (PDAC) cell growth. May play a role as a nucleotide-sugar transporter.
Subunit:
Interacts with SLC25A5.
Subcellular Location:
Mitochondrion. Lysosome membrane; Multi-pass membrane protein.
Tissue Specificity:
Expressed in pancreatic ductal adenocarcinoma (PDAC) (at protein level). Strongly expressed in prostate and thyroid. Weakly expressed in lung, heart, liver and kidney.
Similarity:
Belongs to the SLC35F solute transporter family.
Contains 1 EamA domain.
Database links:Entrez Gene: 54978 Human
SwissProt: Q8N357 Human
SwissProt: Q8VE96 Mouse
SwissProt: Q5RKH7 Rat
Unigene: 516034 Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.