产品中心
当前位置：首页>产品中心Anti-CMYA2/PDE4DIP/AP
货号： bs-9477R-AP 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-9477R-AP
- 英文名称
- Anti-CMYA2/PDE4DIP/AP
- 中文名称
- 碱性磷酸酶（AP）标记的心肌病相关蛋白2抗体
- 别 名
- Cardiomyopathy associated protein 2; Cardiomyopathy-associated protein 2; CMYA2; MMGL; MYOME_HUMAN; Myomegalin; Pde4dip; Phosphodiesterase 4D interacting protein; Phosphodiesterase 4D-interacting protein.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 心血管 信号转导 细胞骨架 细胞外基质
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Sheep,
- 产品应用
- IHC-P=1:50-200 IHC-F=1:50-200 ICC=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 265kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human CMYA2/PDE4DIP
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
May function as an anchor sequestering components of the cAMP-dependent pathway to Golgi and/or centrosomes.Myomegalin, is a 2,346 amino acid protein that contains one NBPF domain and localizes to the nucleus, cytoplasm, centrosome and Golgi apparatus. Expressed at high levels in fetal and adult heart and at lower levels in brain and placenta, myomegalin is thought to function as an anchoring protein that sequesters members of the cAMP-dependent pathway to the Golgi and to centrosomes, thereby mediating cAMP pathway dynamics. Translocations in the gene that encodes myomegalin are associated with myeloproliferative disorders (MBDs), a group of diseases caused by an overproduction of blood cells. Myomegalin exists as twelve isoforms due to alternative splicing events.
Function:
May function as an anchor sequestering components of thecAMP-dependent pathway to Golgi and/or centrosomes (By similarity).
Subunit:
Interacts with PDE4D (By similarity).
Subcellular Location:
Golgi apparatus (By similarity). Cytoplasm,cytoskeleton, centrosome (By similarity). Cytoplasm. Nucleus.
Tissue Specificity:
Highly expressed in heart and skeletal muscle and to a lower extent in brain and placenta.
DISEASE:
Note=A chromosomal aberration involving PDE4DIP may bethe cause of a myeloproliferative disorder (MBD) associated witheosinophilia. Translocation t(1;5)(q23;q33) that forms aPDE4DIP-PDGFRB fusion protein.
Similarity:
Contains 1 NBPF domain.
Database links:Entrez Gene: 9659 Human
Entrez Gene: 83679 Mouse
Entrez Gene: 64183 Rat
Omim: 608117 Human
SwissProt: Q5VU43 Human
SwissProt: Q80YT7 Mouse
SwissProt: Q9WUJ3 Rat
Unigene: 584841 Human
Unigene: 613082 Human
Unigene: 657490 Human
Unigene: 728768 Human
Unigene: 129840 Mouse
Unigene: 48693 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.