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货号： bs-9566R-AP 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-9566R-AP
- 英文名称
- Anti-Osteocrin/AP
- 中文名称
- 碱性磷酸酶（AP）标记的肌肉素抗体
- 别 名
- Musclin; OSTN; OSTN_HUMAN.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 细胞生物 干细胞
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit,
- 产品应用
- IHC-P=1:50-200 IHC-F=1:50-200 ICC=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 3.2kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human Osteocrin (83-133)
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
Musclin, also designated osteocrin (Ostn), shows no homology with any known genes, except that it contains two conserved sequence motifs homologous to the natriuretic peptide family. Musclin is highly expressed in cells of osteoblast lineage and in skeletal muscle tissue, where it is tightly regulated by nutritional changes. It is secreted as either a full-length precursor protein or a processed form. A novel skeletal muscle-derived secretory factor, Musclin may play a role in bone formation and be linked to glucose metabolism. Studies indicate that insulin increases Musclin expression, whereas epinephrine, isoproterenol and forskolin reduce its expression. Musclin is expressed in osteoblasts and young osteocytes. In mouse tissues, expression is bone-specific, although minimal Musclin expression is also observed in muscle, kidney, testis and heart tissues.
Function:
Appears to modulate osteoblastic differentiation. Could also function as an autocrine and paracrine factor linked to glucose metabolism in skeletal muscle.
Subcellular Location:
Secreted.
Tissue Specificity:
Expressed in bone.
Database links:Entrez Gene: 344901 Human
Entrez Gene: 239790 Mouse
Entrez Gene: 360730 Rat
Omim: 610280 Human
SwissProt: P61366 Human
SwissProt: P61364 Mouse
SwissProt: Q149W1 Mouse
SwissProt: P61365 Rat
Unigene: 526794 Human
Unigene: 390880 Mouse
Unigene: 29193 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.