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货号： bs-11543R-AP 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-11543R-AP
- 英文名称
- Anti-Centaurin alpha 1/AP
- 中文名称
- 碱性磷酸酶（AP）标记的Centaurin α1抗体
- 别 名
- ArfGAP with dual PH domains 1; CENTA 1; CENTA1; Centaurin alpha; GCS1L; IP4/PIP3 binding protein; p42IP4; Putative MAPK activating protein PM25; ADAP1_HUMAN.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 细胞生物 神经生物学 信号转导
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Dog, Pig, Cow, Horse, Sheep,
- 产品应用
- WB=1:50-200 IHC-P=1:50-200 IHC-F=1:50-200 ICC=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 43kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human Centaurin alpha 1 (101-200aa)
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
ADP-ribosylation factor (ARF) family of small GTP-binding proteins are involved in vesicular transport regulation and in controlling cytoskeletal organization and cell adhesion. These proteins are best characterized as regulators of membrane traffic. The Centaurin GTPase-activating protein family comprise a subset of ARF regulatory molecules that transduce PI 3-kinase activation into coordinated control of Arf-dependent pathways. This family includes ASAP1, ACAP1, ACAP2, AGAP1, ARAP1, ARAP2, Centaurin a1 and Centaurin g3. The Centaurin a1 protein is a high affinity PtdIns(3,4,5)P3 binding protein enriched in brain. By acting as a GTPase activating protein for ADP ribosylation factor 6 (ARF6), Centaurin a1 is able to switch off ARF6 and inhibit its ability to mediate b2-adrenoceptor internalization and negatively regulate ARF6 activity by functioning as an in vivo PIP3 dependent ARF6 GAP.
Function:
The centaurin alpha 1 protein is a high affinity PtdIns(3,4,5)P3 binding protein enriched in brain. By acting as a GTPase activating protein for ADP ribosylation factor 6 (ARF6), centaurin alpha 1 is able to switch off ARF6 and inhibit its ability to mediate beta 2 adrenoceptor internalization and negatively regulates ARF6 activity by functioning as an in vivo PIP3 dependent ARF6 GAP.
Subunit:
Interacts with PRKCA, PRKCI and PRKCZ. Interacts with the N-terminal region of PRKD1.
Subcellular Location:
Cellular localizationCytoplasmic, Nuclear and Plasma membrane
Tissue Specificity:
Expressed at highest levels in brain and at lower levels in peripheral blood leukocytes.
Post-translational modifications:
Phosphorylated by PRKCA, PRKCI, PRKCZ and PRKD1 in vitro.
Similarity:
Contains 1 Arf-GAP domain.
Contains 2 PH domains.
Database links:
UniProtKB/Swiss-Prot: O75689.2
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.