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货号： bs-12714R-RBITC 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-12714R-RBITC
- 英文名称
- Anti-PLCD1/NDNC3/RBITC
- 中文名称
- 罗丹明（RBITC）标记的磷酸肌醇磷脂酶C抗体
- 别 名
- 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta 1; NDNC3; Phosphoinositide phospholipase C; Phosphoinositide phospholipase C delta 1; Phospholipase C delta 1; Phospholipase C III; PLC delta 1; PLC III.PLCD1_HUMAN
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 细胞生物 免疫学 信号转导
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Pig, Cow, Horse, Rabbit, Sheep, Guinea Pig,
- 产品应用
- ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 86kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human PLCD1/NDNC3
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
This gene encodes a member of the phospholipase C family. Phospholipase C isozymes play critical roles in intracellular signal transduction by catalyzing the hydrolysis of phosphatidylinositol 4,5-bisphosphate (PIP2) into the second messengers diacylglycerol (DAG) and inositol triphosphate (IP3). The encoded protein functions as a tumor suppressor in several types of cancer, and mutations in this gene are a cause of hereditary leukonychia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]
Function:
The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. Essential for trophoblast and placental development.
DISEASE:
The disease is caused by mutations affecting the gene represented in this entry.Disease description:A nail disorder characterized by a white appearance of the nail plate (true leukonychia), the nail bed (pseudoleukonychia), or neither (apparent leukonychia). Leukonychia may involve all of the nail (leukonychia totalis) or only part of the nail (leukonychia partialis), or can appear as one or more transverse bands (leukonychia striata) or white spots (leukonychia punctata).
Similarity:
Contains 1 C2 domain.
Contains 2 EF-hand domains.
Contains 1 PH domain.
Contains 1 PI-PLC X-box domain.
Contains 1 PI-PLC X-box domain.
Database links:Entrez Gene: 281986Cow
Entrez Gene: 5333Human
Entrez Gene: 18799Mouse
Entrez Gene: 100627099Pig
Entrez Gene: 24655Rat
Omim: 602142Human
SwissProt: P51178Human
SwissProt: Q8R3B1Mouse
SwissProt: P10688Rat
Unigene: 80776Human
Unigene: 23963Mouse
Unigene: 12324Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.