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货号： bs-19968R-RBITC 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-19968R-RBITC
- 英文名称
- Anti-PPP2R2D/RBITC
- 中文名称
- 罗丹明（RBITC）标记的蛋白磷酸酶2调节亚基2D抗体
- 别 名
- 2ABD_HUMAN; MDS026; PP2A subunit B isoform B55-delta; PP2A subunit B isoform delta; PP2A subunit B isoform PR55-delta; PP2A subunit B isoform R2-delta; PPP2R2D; Protein phosphatase 2 regulatory subunit B delta; Protein phosphatase 2 regulatory subunit B delta isoform; Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 细胞生物 信号转导 激酶和磷酸酶
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Horse,
- 产品应用
- ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 52kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human PPP2R2D
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- Function:
B regulatory subunit of protein phosphatase 2A (PP2A) that plays a key role in cell cycle by controlling mitosis entry and exit. The activity of PP2A complexes containing PPP2R2D (PR55-delta) fluctuate during the cell cycle: the activity is high in interphase and low in mitosis. During mitosis, activity of PP2A is inhibited via interaction with phosphorylated ENSA and ARPP19 inhibitors. Within the PP2A complexes, the B regulatory subunits modulate substrate selectivity and catalytic activity, and also may direct the localization of the catalytic enzyme to a particular subcellular compartment (By similarity).
Subunit:
PP2A consists of a common heterodimeric core enzyme, composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B/PR72/PR130/PR59 and R5/B/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules. Interacts with ENSA (when phosphorylated at Ser-67) and ARPP19 (when phosphorylated at Ser-62), leading to inhibit PP2A activity (By similarity).
Subcellular Location:
Cytoplasm.
Similarity:
Belongs to the phosphatase 2A regulatory subunit B family.
Contains 7 WD repeats.
Database links:Entrez Gene: 423970Chicken
Entrez Gene: 55844Human
Entrez Gene: 52432Mouse
Entrez Gene: 246255Rat
Entrez Gene: 379305 Xenopus laevis
Entrez Gene: 448324 Xenopus tropicalis
Entrez Gene: 327263Zebrafish
Omim: 613992Human
SwissProt: Q5ZIY5Chicken
SwissProt: Q5E9Q7Cow
SwissProt: Q4R8L3-2 Cynomolgus Monkey
SwissProt: Q66LE6Human
SwissProt: Q925E7Mouse
SwissProt: Q5R4A2Orangutan
SwissProt: Q29090Pig
SwissProt: P63150Rabbit
SwissProt: P56932Rat
SwissProt: Q7ZX64 Xenopus laevis
SwissProt: Q6DIY3 Xenopus tropicalis
SwissProt: Q6NY64Zebrafish
Unigene: 380372Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.