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货号： bs-19903R-RBITC 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-19903R-RBITC
- 英文名称
- Anti-PC4/RBITC
- 中文名称
- 罗丹明（RBITC）标记的正辅因子4抗体
- 别 名
- Activated RNA polymerase II transcriptional coactivator p15; Interferon related developmental regulator 1; MGC102747; p14; P15; PC4; PC4 LSB; Positive cofactor 4; RPO2TC1; Sub1; SUB1 homolog; TCP4_HUMAN
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 细胞生物 表观遗传学
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Zebrafish, Sheep,
- 产品应用
- ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 14kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human PC4
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- Function:
General coactivator that functions cooperatively with TAFs and mediates functional interactions between upstream activators and the general transcriptional machinery. May be involved in stabilizing the multiprotein transcription complex. Binds single-stranded DNA. Also binds, in vitro, non-specifically to double-stranded DNA (ds DNA).
Subunit:
Interacts with PSIP1/LEDGF.
Subcellular Location:
Nucleus.
Tissue Specificity:
Expressed in a variety of tissues.
Post-translational modifications:
Activity is controlled by protein kinases that target the regulatory region.
Phosphorylation inactivates both ds DNA-binding and cofactor function, but does not affect binding to ssDNA. Seems to be phosphorylated in vivo by CK2 in at least 7 sites in the N-terminal Ser-rich region.
Similarity:
Belongs to the transcriptional coactivator PC4 family.
Database links:Entrez Gene: 10923Human
Entrez Gene: 20024Mouse
Entrez Gene: 192269Rat
Omim: 600503Human
SwissProt: P53999Human
SwissProt: P11031Mouse
SwissProt: Q63396Rat
Unigene: 229641Human
Unigene: 644972Human
Unigene: 41746Mouse
Unigene: 8706Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.