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货号： bs-19834R-RBITC 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-19834R-RBITC
- 英文名称
- Anti-REPS2/RBITC
- 中文名称
- 罗丹明（RBITC）标记的REPS2蛋白抗体
- 别 名
- OTTHUMP00000022995; Partner of Ral binding protein 1; Partner of RalBP1; POB1; RALBP1 associated Eps domain containing 2; RALBP1 interacting protein 2; RALBP1-associated Eps domain-containing protein 2; REPS 2.REPS2_HUMAN
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 肿瘤 细胞生物 染色质和核信号 信号转导 G蛋白信号
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit,
- 产品应用
- ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 66kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human REPS2
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
The product of this gene is part of a protein complex that regulates the endocytosis of growth factor receptors. The encoded protein directly interacts with a GTPase activating protein that functions downstream of the small G protein Ral. Its expression can negatively affect receptor internalization and inhibit growth factor signaling. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Function:
Involved in growth factor signaling through its influence on the Ral signaling pathway.
Subunit:
Interacts with ASAP1 and this complex can bind paxillin. May form a ternary complex with RALBP1 and ASAP1 (By similarity). Interacts with RALBP1 and GRB2. Binding to RALBP1 does not affect the Ral-binding activity of the latter. It can form a ternary complex with activated Ral and RALBP1. Binds EPN1.
Subcellular Location:
Cytoplasmic.
Tissue Specificity:
Expressed at high levels in the cerebrum, cerebellum, lung, kidney, and testis. Weakly expressed in the kidney. Relatively highly expressed in androgen-dependent as compared to androgen-independent prostate cancer cell lines and xenografts. Isoform 2 is down-regulated during progression of prostate cancer.
Post-translational modifications:
EGF stimulates phosphorylation on Tyr-residues and induces complex formation with EGF receptor through an adapter protein such as GRB2.
Similarity:
Contains 1 EF-hand domain.
Contains 2 EH domains.
Database links:Entrez Gene: 526887Cow
Entrez Gene: 100056954Horse
Entrez Gene: 9185Human
Entrez Gene: 100353871Rabbit
Entrez Gene: 363466Rat
Omim: 300317Human
SwissProt: Q8NFH8Human
Unigene: 186810Human
Unigene: 207682Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.