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货号： bs-19815R-RBITC 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-19815R-RBITC
- 英文名称
- Anti-SLC25A38/RBITC
- 中文名称
- 罗丹明（RBITC）标记的溶质载体家族蛋白25成员38抗体
- 别 名
- FLJ20551; FLJ22703; S2538_HUMAN; slc25a38; Solute carrier family 25 member 38.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 肿瘤 细胞生物 信号转导
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Cow, Rabbit, Sheep,
- 产品应用
- ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 34kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human SLC25A38
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
This gene is a member of the mitochondrial carrier family. The encoded protein is required during erythropoiesis and is important for the biosynthesis of heme. Mutations in this gene are the cause of autosomal congenital sideroblastic anemia.[provided by RefSeq, Mar 2010]
Function:
Mitochondrial carrier required during erythropoiesis. Probably involved in the biosynthesis of heme, possibly by facilitating 5-aminolevulinate (ALA) production. May act by importing glycine into mitochondria or by exchanging glycine for ALA across the mitochondrial inner membrane.
Subcellular Location:
Mitochondrion inner membrane.
Tissue Specificity:
Preferentially expressed in erythroid cells.
DISEASE:
Defects in SLC25A38 are a cause of anemia sideroblastic pyridoxine-refractory autosomal recessive (PRARSA) [MIM:205950]. A form of sideroblastic anemia not responsive to pyridoxine. Sideroblastic anemia is characterized by anemia of varying severity, hypochromic peripheral erythrocytes, systemic iron overload secondary to chronic ineffective erythropoiesis, and the presence of bone marrow ringed sideroblasts. Sideroblasts are characterized by iron-loaded mitochondria clustered around the nucleus.
Similarity:
Belongs to the mitochondrial carrier family.
SLC25A38 subfamily.
Contains 3 Solcar repeats.
Database links:Entrez Gene: 512325Cow
Entrez Gene: 54977Human
Entrez Gene: 208638Mouse
Entrez Gene: 301067Rat
Entrez Gene: 100147784Sheep
Omim: 610819Human
SwissProt: Q5EAC0Cow
SwissProt: Q96DW6Human
SwissProt: Q91XD8Mouse
SwissProt: Q499U1Rat
SwissProt: S2538Sheep
Unigene: 369615Human
Unigene: 236656Mouse
Unigene: 21048Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.