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货号： bs-3638R 基本售价： 1380.0 元 规格： 100ul
- 规格：100ul
- 价格：1380.00元
- 规格：200ul
- 价格：2200.00元
产品信息
- 产品编号
- bs-3638R
- 英文名称
- Plexin A2
- 中文名称
- 神经丛蛋白A2抗体
- 别 名
- PlexinA2; PLXA2; PLXNA2; Semaphorin receptor OCT.
- 规格价格
- 100ul/1380元购买 200ul/2200元购买 大包装/询价
- 说 明 书
- 100ul 200ul
- 研究领域
- 免疫学 神经生物学 细胞膜受体 细胞表面分子
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat,
- 产品应用
- WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 205kDa
- 细胞定位
- 细胞膜
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human Plexin A2:1251-1400/1894 <Extracellular>
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- PubMed
- PubMed
- 产品介绍
- background:
Plexin A2 is a coreceptor for SEMA3A and is necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. This coreceptor plays a role in axon guidance, invasive growth and cell migration. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin in which the plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm.
Function:
Coreceptor for SEMA3A and SEMA6A. Necessary for signaling by SEMA6A and class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm (By similarity).
Subunit:
Homodimer. The PLXNA2 homodimer interacts with a SEMA6A homodimer, giving rise to a heterotetramer. Interacts directly with NRP1 and NRP2 (By similarity). Interacts with RND1.
Subcellular Location:
Cell membrane; Single-pass type I membrane protein (By similarity).
Tissue Specificity:
Detected in fetal brain.
Similarity:
Belongs to the plexin family.
Contains 4 IPT/TIG domains.
Contains 1 Sema domain.
SWISS:
O75051
Gene ID:
5362
Database links:Entrez Gene: 5362 Human
Entrez Gene: 18845 Mouse
Entrez Gene: 289392 Rat
Omim: 601054 Human
SwissProt: O75051 Human
SwissProt: P70207 Mouse
Unigene: 497626 Human
Unigene: 2251 Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
Plexin A2蛋白是SEMA3A的辅助受体，Plexin A2蛋白在神经细胞轴突导向, 生长和细胞迁移中发挥作用。