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货号： bs-10998R-RBITC 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-10998R-RBITC
- 英文名称
- Anti-phospho-IRS-2(Ser731)/RBITC
- 中文名称
- 罗丹明（RBITC）标记的磷酸化胰岛素受体底物2抗体
- 别 名
- IRS-2(phospho-Ser731); IRS-2(phospho S731); Insulin Receptor Substrate 2; IRS 2; IRS-2; IRS2; IRS2_HUMAN.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 心血管 细胞生物 免疫学 神经生物学 信号转导 生长因子和激素 转录调节因子 糖尿病
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Dog, Horse,
- 产品应用
- ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 147kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated Synthesised phosphopeptide derived from human IRS-2 around the phosphorylation site of Ser731
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
The family of insulin receptor substrates (IRSs) has been reported to play important roles for signal transduction of various hormones. Four members of the IRS family have been described. Each IRS is believed to have different functions; however, the distinct physiological roles of each IRS are unclear. Summary: This gene encodes the insulin receptor substrate 2, a cytoplasmic signaling molecule that mediates effects of insulin, insulin-like growth factor 1, and other cytokines by acting as a molecular adaptor between diverse receptor tyrosine kinases and downstream effectors. The product of this gene is phosphorylated by the insulin receptor tyrosine kinase upon receptor stimulation, as well as by an interleukin 4 receptor-associated kinase in response to IL4 treatment.
Function:
May mediate the control of various cellular processes by insulin.
Subunit:
Interacts with PHIP.
Subcellular Location:
Cytoplasm, cytosol.
Post-translational modifications:
Phosphorylated upon DNA damage, probably by ATM or ATR.
Similarity:
Contains 1 IRS-type PTB domain.
Contains 1 PH domain.
Database links:Entrez Gene: 8660 Human
Entrez Gene: 384783 Mouse
Entrez Gene: 29376 Rat
Omim: 600797 Human
SwissProt: Q9Y4H2 Human
SwissProt: P81122 Mouse
Unigene: 442344 Human
Unigene: 407207 Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.