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货号： bs-19065R-RBITC 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-19065R-RBITC
- 英文名称
- Anti-NDST4/RBITC
- 中文名称
- 罗丹明（RBITC）标记的NDST4蛋白抗体
- 别 名
- Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 4; BSST4; Glucosaminyl N-deacetylase/N-sulfotransferase 4; Heparan sulfate N-sulfotransferase 4; N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 4; N-heparan sulfate sulfotransferase 4; N-HSST 4; NDST-4; Ndst4; NDST4_HUMAN; NHSST 4.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 细胞生物 信号转导
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Sheep,
- 产品应用
- ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 101kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human NDST4
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
The N-deacetylation and N-sulfation of N-acetylglucosamine residues in heparan sulfate and heparin initiate a set of biochemical reactions, which lead to the synthesis of oligosaccharide sequences that have specific ligand binding properties (1). These reactions are catalyzed by the monomeric enzymes GlcNAc Ndeacetylase/N-sulfotransferases (NDSTs), which have two catalytic activities (1). Multiple NDST isozymes have been identified, each having unique tissue distribution and enzymatic properties (2). Phylogenetic data suggests that NDST1-4 evolved from a common ancestral gene, which diverged to give rise to two subtypes, NDST1/2 and NDST3/4 (2). NDST1, which maps to human chromosome 5q32-q33.1, shares the most homology with NDST2, which maps to human chromosome 10q22 (3,4). The least conserved amino acids between these two enzymes are found in the N-terminus/putative transmembrane regions (3). The human NDST3 and NDST4 genes are closely linked on chromosome 4, mapping to chromosome 4q25-26 and 4q26-27, respectively (2,5,6). RT-PCR analysis of various mouse tissues reveals a restricted pattern of NDST3 and NDST4 mRNA expression when compared with that of NDST1 and NDST2, which are abundantly and ubiquitously expressed (2).
Function:
Essential bifunctional enzyme that catalyzes both the N-deacetylation and the N-sulfation of glucosamine (GlcNAc) of the glycosaminoglycan in heparan sulfate. Modifies the GlcNAc-GlcA disaccharide repeating sugar backbone to make N-sulfated heparosan, a prerequisite substrate for later modifications in heparin biosynthesis. Has low deacetylase activity but high sulfotransferase activity
Subunit:
Monomer
Subcellular Location:
Golgi apparatus membrane; Single-pass type II membrane protein
Similarity:
Belongs to the sulfotransferase 1 family. NDST subfamily.
Database links:Entrez Gene: 64579Human
Entrez Gene: 64580Mouse
Entrez Gene: 362035Rat
Omim: 615039Human
SwissProt: Q9H3R1Human
SwissProt: Q9EQW8Mouse
Unigene: 591700Human
Unigene: 444289Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.