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货号： bs-18228R-RBITC 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-18228R-RBITC
- 英文名称
- Anti-PGAM5/RBITC
- 中文名称
- 罗丹明（RBITC）标记的丝氨酸/苏氨酸蛋白磷酸酶PGAM5抗体
- 别 名
- Bcl-XL-binding protein v68; BXLBv68; MGC5352; mitochondrial; PGAM5; PGAM5_HUMAN; Phosphoglycerate mutase family member 5; Serine/threonine protein phosphatase PGAM5 mitochondrial; Serine/threonine-protein phosphatase PGAM5.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 细胞生物 信号转导 激酶和磷酸酶 线粒体
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Horse, Rabbit,
- 产品应用
- ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 32kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human PGAM5
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
Members of the PGAM (phosphoglycerate mutase) family of proteins are important components of glucose and 2,3-BPGA (2,3-bisphosphoglycerate) metabolism. They are responsible for catalyzing the transfer of phospho groups between the carbon atoms of phosphoglycerates. PGAM5 (phosphoglycerate mutase family member 5), also known as Bcl-xL-binding protein v68, is a 289 amino acid protein belonging to the BPG-dependent PGAM subfamily. PGAM5 exists as two isoforms produced by alternative splicing events, with isoform two localized to the cytoplasm and isoform one localized to both the cytoplasm and the nucleus. PGAM5 forms a dimer and has been found to interact with Bcl-xS/L and Keap1.
Function:
Displays phosphatase activity for serine/threonine residues, and, dephosphorylates and activates MAP3K5 kinase. Has apparently no phosphoglycerate mutase activity. May be regulator of mitochondrial dynamics. Substrate for a KEAP1-dependent ubiquitin ligase complex. Contributes to the repression of NFE2L2-dependent gene expression.
Subcellular Location:
Mitochondrion. Mitochondrion outer membrane. Membrane. Isoform 2 overexpression results in the formation of disconnected punctuate mitochondria distributed throughout the cytoplasm. Isoform 1 overexpression results in the clustering of mitochondria around the nucleus.
Similarity:
Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.
Database links:Entrez Gene: 192111Human
Entrez Gene: 72542Mouse
Entrez Gene: 288731Rat
SwissProt: Q96HS1Human
SwissProt: Q8BX10Mouse
SwissProt: Q562B5Rat
Unigene: 102558Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.