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货号： bs-18173R-RBITC 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-18173R-RBITC
- 英文名称
- Anti-Intrinsic Factor/RBITC
- 中文名称
- 罗丹明（RBITC）标记的胃内在因子抗体
- 别 名
- Gastric Intrinsic Factor; Gastric intrinsic factor (vitamin B synthesis); GIF; IF; IFMH; INF; Intrinsic factor; TCM3; TCN3.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 细胞生物 免疫学 信号转导
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat,
- 产品应用
- ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 43kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human Intrinsic Factor
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
This gene is a member of the cobalamin transport protein family. It encodes a glycoprotein secreted by parietal cells of the gastric mucosa and is required for adequate absorption of vitamin B12. Vitamin B12 is necessary for erythrocyte maturation and mutations in this gene may lead to congenital pernicious anemia. [provided by RefSeq, Jul 2008]
Function:
Intrinsic factor promotes absorption of the essential vitamin Cobalamin (Cbl) in the ileum by specific receptor mediated endocytosis. Defects in the gene GIF are the cause of hereditary intrinsic factor deficiency (IFD) also called congenital pernicious anemia. IFD is an autosomal recessive disorder characterized by megaloblastic anemia.
Subcellular Location:
Secreted
Tissue Specificity:
Gastric mucosa.
DISEASE:
Hereditary intrinsic factor deficiency (IFD)
Similarity:
Belongs to the eukaryotic cobalamin transport proteinsfamily.
Database links:Entrez Gene: 2694Human
Entrez Gene: 14603Mouse
Entrez Gene: 29319Rat
Omim: 609342Human
SwissProt: P27352Human
SwissProt: P52787Mouse
SwissProt: P17267Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.