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货号： bs-18171R-RBITC 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-18171R-RBITC
- 英文名称
- Anti-Intersectin 1/RBITC
- 中文名称
- 罗丹明（RBITC）标记的交叉蛋白1抗体
- 别 名
- Human intersectin SH3 domain containing protein SH3P17; Intersectin 1 SH3 domain protein; intersectin 1 short form variant 3; intersectin 1 short form variant, 11; Intersectin short form; intersectin short variant 12; Intersectin-1; Intersectin1; ITSN 1; ITSN; itsn1; ITSN1_HUMAN; MGC134948; MGC134949; OTTHUMP00000067855; OTTHUMP00000067856; OTTHUMP00000067857; OTTHUMP00000194810; OTTHUMP00000194811; OTTHUMP00000194812; OTTHUMP00000206688; SH3 domain containing protein 1A; SH3 domain protein 1A; SH3 domain-containing protein 1A; SH3D1A; SH3P17; Src homology 3 domain containing protein.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 细胞生物 免疫学
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Dog, Cow, Horse, Rabbit, Sheep,
- 产品应用
- ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 195kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human Intersectin 1
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
The protein encoded by this gene is a cytoplasmic membrane-associated protein that indirectly coordinates endocytic membrane traffic with the actin assembly machinery. In addition, the encoded protein may regulate the formation of clathrin-coated vesicles and could be involved in synaptic vesicle recycling. This protein has been shown to interact with dynamin, CDC42, SNAP23, SNAP25, SPIN90, EPS15, EPN1, EPN2, and STN2. Multiple transcript variants encoding different isoforms have been found for this gene, but the full-length nature of only two of them have been characterized so far. [provided by RefSeq, Jul 2008]
Function:
Adapter protein that may provide indirect link between the endocytic membrane traffic and the actin assembly machinery. May regulate the formation of clathrin-coated vesicles. Isoform 1 could be involved in brain-specific synaptic vesicle recycling. Inhibits ARHGAP31 activity toward RAC1.
Subcellular Location:
Endomembrane system. Cell junction > synapse > synaptosome. Cell projection >lamellipodium.
Tissue Specificity:
Isoform 2 is ubiquitous in adult and fetal tissues with high expression in skeletal muscle, heart, spleen, ovary, testis and all fetal tissues tested and low expression in thymus, blood, lung, liver and pancreas. Isoform 1 is expressed almost exclusively in the brain, in all brain regions. Not expressed in the spinal cord.
Similarity:
Contains 1 C2 domain.
Contains 1 DH (DBL-homology) domain.
Contains 2 EF-hand domains.
Contains 2 EH domains.
Contains 1 PH domain.
Contains 5 SH3 domains.
Database links:Entrez Gene: 6453Human
Entrez Gene: 16443Mouse
Entrez Gene: 29491Rat
Omim: 602442Human
SwissProt: Q15811Human
SwissProt: Q9Z0R4Mouse
SwissProt: Q9WVE9Rat
Unigene: 160324Human
Unigene: 40546Mouse
Unigene: 48657Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.