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货号： bs-18167R-RBITC 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-18167R-RBITC
- 英文名称
- Anti-TOE1/RBITC
- 中文名称
- 罗丹明（RBITC）标记的早期生长应答蛋白1靶向蛋白1抗体
- 别 名
- Target of EGR1 protein 1; target of EGR1, member 1; Toe1; TOE1_HUMAN.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 细胞生物 免疫学 细胞周期蛋白
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human,
- 产品应用
- ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 57kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human TOE1
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
TOE1 is a 510 amino acid long protein that belongs to the CAF1 family. It is a downstream target of EGR-1 and plays an important role mediating the inhibitory growth effect of EGR-1. EGR-1 directly binds the TOE1 promoter region and activates its expression. TOE1 induces the expression of TGF∫ and p21 and plays a role in cell cycle regulation and the inhibition of cell growth. The activity and nucleolar localization of TOE1 correlates with a G2 cell cycle phase delay which is likely due to an increased expression of p21. In addition, TOE1 may function via an interaction with p53 and possible modification to its activity. TOE1 is expressed at various levels in all adult tissues and specifically localizes to the nuclear speckles.
Function:
Inhibits cell growth rate and cell cycle. Induces CDKN1A expression as well as TGF-beta expression. Mediates the inhibitory growth effect of EGR1.
Subcellular Location:
Nucleus > nucleolus. Nucleus speckle. Localizes to nuclear speckles.
Similarity:
Belongs to the CAF1 family.
Contains 1 C3H1-type zinc finger.
Database links:Entrez Gene: 114034Human
Entrez Gene: 68276Mouse
Entrez Gene: 298443Rat
Omim: 613931Human
SwissProt: Q96GM8Human
SwissProt: Q9D2E2Mouse
Unigene: 525091Human
Unigene: 30534Mouse
Unigene: 105772Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.