产品中心
当前位置：首页>产品中心Anti-TNPO2/RBITC
货号： bs-18157R-RBITC 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-18157R-RBITC
- 英文名称
- Anti-TNPO2/RBITC
- 中文名称
- 罗丹明（RBITC）标记的转运蛋白2抗体
- 别 名
- Importin 3; IPO3; Karyopherin beta 2b, transportin; KPNB2B; TNPO2; Transportin 2 (importin 3, karyopherin beta 2b); Transportin 2 (Importin 3, karyopherin beta 2b), isoform CRA b; Transportin 2; TRN2.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 细胞生物 免疫学 信号转导
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Dog, Pig, Cow, Horse,
- 产品应用
- ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 60, 100kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human TNPO2
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
Protein transport across the nucleus is a selective, multi-step process involving several cytoplasmic factors. Proteins must be recognized as import substrates, dock at the nuclear pore complex and translocate across the nuclear envelope in an ATP-dependent fashion. Two cytosolic factors centrally involved in the recognition and docking process are the karyopherin alpha 1 and karyopherin beta1 subunits. Karyopherin alpha 1 functions in the recognition and targeting of substrates destined for nuclear import, while karyopherin beta 1 serves as an adapter, tethering the karyopherin alpha 1/substrate complex to docking proteins on the nuclear envelope, termed nucleoporins. Karyopherin alpha 2 has been shown to complex with Epstein-Barr virus nuclear antigen 1 (EBNA-1). Karyopherin beta 2 and karyopherin beta 2B (also designated transportin 1 and transportin 2) share 84% sequence identity at the amino acid level, however, they have been shown to have different substrate specificities. Karyopherin beta 2 mediates hnRNPA1 nuclear import while karyopherin beta 2B has been implicated in the export of cellular mRNAs through complexes formed with the mRNA export factor TAP.
Function:
Transportin 2 (TNPO2) mediates nuclear import of HuR protein in vitro. It also participates in mRNA export from the nucleus.
Subcellular Location:
Cytoplasm Nucleus
Similarity:
Belongs to the importin beta family.
Contains 13 HEAT repeats.
Contains 1 importin N-terminal domain.
Database links:Entrez Gene: 30000Human
Entrez Gene: 212999Mouse
Entrez Gene: 304670Rat
Omim: 603002Human
SwissProt: O14787Human
SwissProt: Q6IN77Human
SwissProt: Q99LG2Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.