产品中心
当前位置：首页>产品中心Anti-HspBP1/RBITC
货号： bs-18085R-RBITC 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-18085R-RBITC
- 英文名称
- Anti-HspBP1/RBITC
- 中文名称
- 罗丹明（RBITC）标记的热休克蛋白70结合蛋白1抗体
- 别 名
- 1500019G21Rik; FES1; Heat shock protein 70 binding protein; Heat shock protein 70 interacting protein; Heat shock protein binding protein 1; Heat shock protein-binding protein 1; Heat-shock 70-KD protein-binding protein 1; HPBP1_HUMAN; Hsp 70 binding protein; Hsp 70 interacting protein; Hsp70 binding protein 1; Hsp70 binding protein 2; Hsp70 interacting protein 1; Hsp70 interacting protein 2; Hsp70-binding protein 1; Hsp70-binding protein 2; Hsp70-interacting protein 1; Hsp70-interacting protein 2; HSPA (heat shock 70kDa) binding protein, cytoplasmic cochaperone 1; HSPA-binding protein 1; HSPBP; HspBP1; HspBP2; PP1845.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 细胞生物 信号转导 结合蛋白
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep,
- 产品应用
- ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 39kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human HspBP1
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
Hsp70-interacting protein (HspBP1) belongs to a family of eukaryotic proteins identified as nucleotide exchange factors for Hsp70, which exhibit varying degrees of compartment and species specificity. HspBP1 interferes with the CHIP-induced degradation of immature forms of the cystic fibrosis transmembrane conductance regulator (CFTR) and stimulates CFTR maturation. HspBP1 binds to Hsp70, inhibits its activity and promotes dissociation of nucleotides from the Hsp70 ATPase domain. It is a protein mainly expressed in heart and skeletal muscle.
Function:
Inhibits HSPA1A chaperone activity by changing the conformation of the ATP-binding domain of HSPA1A and interfering with ATP binding. Interferes with ubiquitination mediated by STUB1 and inhibits chaperone-assisted degradation of immature CFTR.
Tissue Specificity:
Ubiquitous.
Similarity:
Contains 4 ARM repeats.
Database links:Entrez Gene: 23640Human
Entrez Gene: 66245Mouse
Entrez Gene: 246146Rat
Omim: 612939Human
SwissProt: Q9NZL4Human
SwissProt: Q99P31Mouse
SwissProt: Q6IMX7Rat
Unigene: 53066Human
Unigene: 6803Mouse
Unigene: 4297Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.