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货号： bs-17858R-RBITC 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-17858R-RBITC
- 英文名称
- Anti-MSL3L1/RBITC
- 中文名称
- 罗丹明（RBITC）标记的MSL3L1蛋白抗体
- 别 名
- MSL3; AU018931; DKFZp586J1822; Drosophila MSL3 like 1; Male specific lethal 3 (Drosophila) like 1; Male specific lethal 3 homolog (Drosophila); Male specific lethal 3 homolog 1 (Drosophila); Male specific lethal 3 homolog 1; Male specific lethal 3 homolog; Male specific lethal 3 like 1 (Drosophila); Male specific lethal 3 like 1; Male specific lethal 3 protein like 1; Male-specific lethal 3 homolog; Male-specific lethal-3 homolog 1; Male-specific lethal-3 protein-like 1; MS3L1_HUMAN; MSL3; MSL3 like 1; MSL3-like 1; Msl31; MSL3L1; OTTHUMP00000022911; OTTHUMP00000022912.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 细胞生物 发育生物学 转录调节因子 表观遗传学
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Dog, Pig, Cow, Horse, Sheep, Guinea Pig,
- 产品应用
- ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 60kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human MSL3L1
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
This gene encodes a nuclear protein that is similar to the product of the Drosophila male-specific lethal-3 gene. The Drosophila protein plays a critical role in a dosage-compensation pathway, which equalizes X-linked gene expression in males and females. Thus, the human protein is thought to play a similar function in chromatin remodeling and transcriptional regulation, and it has been found as part of a complex that is responsible for histone H4 lysine-16 acetylation. This gene can undergo X inactivation. Alternative splicing results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 2, 7 and 8. [provided by RefSeq, Jul 2010]
Function:
May be involved in chromatin remodeling and transcriptional regulation. May have a role in X inactivation. Component of the MSL complex which is responsible for the majority of histone H4 acetylation at Lys-16 which is implicated in the formation of higher-order chromatin structure. Specificallyrecognizes histone H4 monomethylated at Lys-20 (H4K20Me1) in a DNA-dependent manner and is proposed to be involved in chromosomal targeting of the MSL complex.
Subunit:
Component the MSL histone acetyltransferase complex at least composed of the MOF/KAT8, MSL1/hampin, MSL2 and MSL3. Interacts (via the MRG domain) with MSL1.
Subcellular Location:
Nucleus
Tissue Specificity:
Expressed in many tissues including liver, pancreas, heart, lung, kidney, skeletal muscle, brain, and placenta, with highest expression in skeletal muscle and heart.
Similarity:
Contains 1 chromo domain.
Contains 1 MRG domain.
Database links:Entrez Gene: 515220Cow
Entrez Gene: 10943Human
Entrez Gene: 17692Mouse
Entrez Gene: 317464Rat
Omim: 300609Human
SwissProt: Q8N5Y2Human
SwissProt: Q9WVG9Mouse
Unigene: 655288Human
Unigene: 400572Mouse
Unigene: 490444Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.