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货号： bs-17851R-RBITC 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-17851R-RBITC
- 英文名称
- Anti-MSH4/RBITC
- 中文名称
- 罗丹明（RBITC）标记的MSH4蛋白抗体
- 别 名
- MSH 4; MutS homolog 4 (E. Coli); MutS homolog 4; MutS protein homolog 4.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 细胞生物 表观遗传学
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Pig, Cow, Horse, Sheep,
- 产品应用
- ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 105kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human MSH4
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
This gene encodes a member of the DNA mismatch repair mutS family. This member is a meiosis-specific protein that is not involved in DNA mismatch correction, but is required for reciprocal recombination and proper segregation of homologous chromosomes at meiosis I. This protein and MSH5 form a heterodimer which binds uniquely to a Holliday Junction and its developmental progenitor, thus provoking ADP-ATP exchange, and stabilizing the interaction between parental chromosomes during meiosis double-stranded break repair. [provided by RefSeq, Aug 2011]
Function:
The Escherichia coli MutHLS system has been highly conserved throughout evolution. The eukaryotic pathway results in a specialization of MutS homologs such as MSH2 that have evolved to play crucial roles in both DNA mismatch repair and meiotic recombination. In Saccharomyces cerevisiae, MSH4 is a meiosis-specific protein that is not involved in mismatch correction. This protein is required for reciprocal recombination and proper segregation of homologous chromosomes at meiosis I.
Subunit:
Heterooligomer of MSH4 and MSH5.
Subcellular Location:
Nuclear
Tissue Specificity:
Testis and ovary specific.
Similarity:
Belongs to the DNA mismatch repair MutS family.
Database links:Entrez Gene: 4438Human
Entrez Gene: 55993Mouse
Omim: 602105Human
SwissProt: O15457Human
SwissProt: Q99MT2Mouse
Unigene: 216639Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.