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货号： bs-17730R-RBITC 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-17730R-RBITC
- 英文名称
- Anti-Mov10/RBITC
- 中文名称
- 罗丹明（RBITC）标记的莫洛尼白血病病毒蛋白10抗体
- 别 名
- DKFZp667O1423; FLJ32791; fSAP113; Functional spliceosome-associated protein 113; gb110; MGC2948; MOV10_MOUSE; Moloney leukemia virus 10 protein; MOV 10; Mov10 (Moloney leukemia virus 10, mouse) homolog; Mov10 (Moloney leukemia virus 10,) homolog; Mov10, Moloney leukemia virus 10, homolog (mouse); Mov10, Moloney leukemia virus 10, homolog; Putative helicase MOV10.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 细胞生物 淋巴细胞 b-淋巴细胞 表观遗传学
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Dog, Pig, Cow, Horse, Sheep,
- 产品应用
- ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 114kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from mouse Mov10
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
MOV10 is a RNA helicase that is required for RNA-mediated gene silencing by RISC (RNA-induced silencing complex). Significantly, MOV10 is also required for the transcription and replication of the human hepatitis delta virus, also known as hepatitis D. Belonging to the same family as MOV10, MOV10L1 (Moloney leukemia virus 10-like protein 1) is a 1211 amino acid RNA helicase that is expressed as three isoforms. Interestingly, isoform 1 is expressed exclusively in testis and isoform 2 is specifically expressed in cardiac myocytes. Isoform 1 may play a role in male germ cell development, whereas isoform 2 has been shown to potentiate phenylephrine-induced hypertrophic response in cardiomyocytes. Each isoform contains a RNA interaction motif, ATP binding site and helicase motif through which it carries out its function.
Function:
MOV10 may be an helicase with an important function in development and/or control of cell proliferation. RNA silencing processes are guided by small RNAs known as siRNAs and microRNAs (miRNAs). They reside in ribonucleoprotein complexes, which guide the cleavage of complementary mRNAs or affect stability and translation of partial complementary mRNAs. Argonaute (Ago) proteins are at the heart of silencing effector complexes and bind the single-stranded siRNA and miRNA. Ago1- and Ago2-containing complexes have been purified from human cells, resulting in the discovery of novel factors such as the putative RNA helicase MOV10, and the RNA recognition motif (RRM)-containing protein TNRC6B/KIAA1093. The new proteins localize, similar to Ago proteins, to mRNA-degrading cytoplasmic P bodies, and they are functionally required to mediate miRNA-guided mRNA cleavage.
Subcellular Location:
Cytoplasmic.
Database links:Entrez Gene: 17454Mouse
Entrez Gene: 4343Human
Entrez Gene: 100458347 Orangutan
Omim: 610742Human
SwissProt: Q0V8H6Cow
SwissProt: Q9HCE1Human
SwissProt: P23249Mouse
Unigene: 514941Human
Unigene: 1597Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.