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货号： bs-17678R-RBITC 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-17678R-RBITC
- 英文名称
- Anti-SPIRE2/RBITC
- 中文名称
- 罗丹明（RBITC）标记的SPIRE2蛋白抗体
- 别 名
- MGC117166; Protein spire homolog 2; Spir-2; SPIR2_HUMAN; Spire homolog 2 (Drosophila); SPIRE2.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 肿瘤 细胞生物 神经生物学 信号转导 细胞骨架
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Sheep,
- 产品应用
- ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 80kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human SPIRE2
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
Spir-2 is a 714 amino acid protein belonging to the spire family. Spir-2 is a cytoplasmic protein that contains one KIND domain and three WH2 domains. Spir-2 binds to actin via the WH2 domains and acts as an actin nucleation factor. Spir-2 is involved in vesicle transport and acts as a link between actin organization and intracellular transport. Spir-2 is expressed as four isoforms that are produced by alternative splicing events. The gene that encodes Spir-2 maps to human chromosome 16, which encodes over 900 genes and approximately 90 million base pairs, making up nearly 3% of human cellular DNA. The GAN gene is located on chromosome 16 and, with mutation, may lead to giant axonal neuropathy, a nervous system disorder characterized by increasing malfunction with growth. The rare disorder Rubinstein-Taybi syndrome is also associated with chromosome 16, though through the CREBBP gene which encodes a critical CREB binding protein. Signs of Rubinstein-Taybi include mental retardation and predisposition to tumor growth and white blood cell neoplasias. Crohns disease is a gastrointestinal inflammatory condition associated with chromosome 16 through the NOD2 gene.
Function:
Acts as a actin nucleation factor, remains associated with the slow-growing pointed end of the new filament. Involved in vesicle transport processes providing a novel link between actin organization and intracellular transport.
Subcellular Location:
Cytoplasm >cytoskeleton.
Similarity:
Belongs to the spire family.
Contains 1 KIND domain.
Contains 3 WH2 domains.
Database links:Entrez Gene: 84501Human
Entrez Gene: 234857Mouse
Entrez Gene: 307925Rat
Omim: 609217Human
SwissProt: Q8WWL2Human
SwissProt: Q8K1S6Mouse
Unigene: 461786Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.