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货号： bs-17663R-RBITC 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-17663R-RBITC
- 英文名称
- Anti-SPIB/RBITC
- 中文名称
- 罗丹明（RBITC）标记的转录因子SPIB蛋白抗体
- 别 名
- SPI B; Spi B transcription factor; Spib; SPIB_HUMAN; Transcription factor Spi-B.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 细胞生物 转录调节因子 表观遗传学
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Cow, Horse, Rabbit, Sheep,
- 产品应用
- ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 29kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human SPIB
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
The protein encoded by this gene is a transcriptional activator that binds to the PU-box (5-GAGGAA-3) and acts as a lymphoid-specific enhancer. Four transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]
Function:
Sequence specific transcriptional activator which binds to the PU-box, a purine-rich DNA sequence (5-GAGGAA-3) that can act as a lymphoid-specific enhancer. Promotes development of plasmacytoid dendritic cells (pDCs), also known as type 2 DC precursors (pre-DC2) or natural interferon (IFN)-producing cells. These cells have the capacity to produce large amounts of interferon and block viral replication. May be required for B-cell receptor (BCR) signaling, which is necessary for normal B-cell development and antigenic stimulation.
Subcellular Location:
Cytoplasm and Nucleus.
Tissue Specificity:
Expressed in plasmacytoid dendritic cells (pDCs) and B-cells, not expressed in T-cells or granulocytes. May also be enriched in stem cell populations of the liver.
Similarity:
Belongs to the ETS family.
Contains 1 ETS DNA-binding domain.
Database links:Entrez Gene: 6689Human
Entrez Gene: 272382Mouse
Entrez Gene: 499146Rat
Omim: 606802Human
SwissProt: Q01892Human
SwissProt: O35906Mouse
SwissProt: Q5EBA3Rat
Unigene: 437905Human
Unigene: 8012Mouse
Unigene: 18257Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.