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货号： bs-17643R-RBITC 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-17643R-RBITC
- 英文名称
- Anti-SPCS3/RBITC
- 中文名称
- 罗丹明（RBITC）标记的信号肽复合物亚基3抗体
- 别 名
- DKFZp564J1864; FLJ22649; Microsomal signal peptidase 22/23 kDa subunit; Microsomal signal peptidase 23 kDa subunit; PRO3567; Signal peptidase complex subunit 3; Signal peptidase complex subunit 3 homolog (S. cerevisiae); Signal peptidase complex subunit 3 homolog; SPase 22 kDa subunit; SPase 22/23 kDa subunit; SPC22; SPC22/23; SPC3; UNQ1841; YLR066W.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 细胞生物 信号转导 表观遗传学
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Cow, Horse,
- 产品应用
- ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 20kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human SPCS3
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
SPCS3 (signal peptidase complex subunit 3), also known as SPC3, is a 180 amino acid single-pass type II membrane protein that localizes to both the microsome and the endoplasmic reticulum (ER) and belongs to the SPCS (signal peptidase complex subunit) family. Existing as a component of the microsomal signal peptidase complex which consists of five members, SPCS3 functions to remove signal peptides from proteins that are translated to the lumen of the ER. The gene encoding SPCS3 maps to human chromosome 4, which encodes nearly 6% of the human genome and has the largest gene deserts (regions of the genome with no protein encoding genes) of all of the human chromosomes. Defects in some of the genes located on chromosome 4 are associated with Huntingtons disease, Ellis-van Creveld syndrome, methylmalonic acidemia and polycystic kidney disease.
Function:
A component of the microsomal signal peptidase complex which removes signal peptides from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum.
Subunit:
Component of the microsomal signal peptidase complex which consists of five members: SEC11A, SEC11C, SPCS1, SPCS2 and SPCS3.
Subcellular Location:
Endoplasmic reticulum and Microsome membrane;: Single-pass type II membrane protein
Similarity:
Belongs to the SPCS3 family.
Database links:Entrez Gene: 767917Cow
Entrez Gene: 404005Dog
Entrez Gene: 60559Human
Entrez Gene: 76219Mouse
Entrez Gene: 76976Mouse
Entrez Gene: 100360464Rat
Entrez Gene: 317409Rat
SwissProt: Q3SZU5Cow
SwissProt: P61008Dog
SwissProt: P61009Human
SwissProt: Q9D365Mouse
SwissProt: Q568Z4Rat
Unigene: 6322Cow
Unigene: 3875Dog
Unigene: 42194Human
Unigene: 328305Mouse
Unigene: 482965Mouse
Unigene: 162344Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.