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货号： bs-17641R-RBITC 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-17641R-RBITC
- 英文名称
- Anti-SPCS2/RBITC
- 中文名称
- 罗丹明（RBITC）标记的信号肽复合物亚基2抗体
- 别 名
- Microsomal signal peptidase 25 kDa subunit; Signal peptidase complex subunit 2; Signal peptidase complex subunit 2 homolog (S. cerevisiae); SPase 25 kDa subunit; SPCS2; SPCS2_HUMAN.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 细胞生物 免疫学 信号转导
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Zebrafish,
- 产品应用
- ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 25kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human SPCS2
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
SPCS2 is a 226 amino acid multi-pass membrane protein that localizes to both the microsome and the endoplasmic reticulum (ER), and belongs to the SPCS (signal peptidase complex subunit) family. Existing as a component of the microsomal signal peptidase complex which consists of five members, SPCS2 removes signal peptides from nascent proteins as they are translocated into the lumen of the ER. The gene encoding SPCS2 is located on human chromosome 11, which houses over 1,400 genes and comprises nearly 4% of the human genome. Jervell and Lange-Nielsen syndrome, Jacobsen syndrome, Niemann-Pick disease, hereditary angioedema and Smith-Lemli-Opitz syndrome are associated with defects in genes that maps to chromosome 11.
Function:
Component of the microsomal signal peptidase complex which removes signal peptides from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum.
Subunit:
Component of the microsomal signal peptidase complex which consists of five members: SEC11A, SEC11C, SPCS1, SPCS2 and SPCS3.
Subcellular Location:
Microsome membrane. Endoplasmic reticulum membrane.
Similarity:
Belongs to the SPCS2 family.
Database links:Entrez Gene: 9789Human
Entrez Gene: 66624Mouse
Entrez Gene: 293142Rat
SwissProt: Q15005Human
SwissProt: Q9CYN2Mouse
Unigene: 282700Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.