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货号： bs-17578R-RBITC 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-17578R-RBITC
- 英文名称
- Anti-OXR1/RBITC
- 中文名称
- 罗丹明（RBITC）标记的抗氧化蛋白1抗体
- 别 名
- C7; C7B; Gm1238; Nbla00307; Nucleolar protein C7; Oxidation resistance 1; Oxidation resistance protein 1; Oxr1; OXR1_HUMAN; Putative protein product of Nbla00307; rCG_59825.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 细胞生物 免疫学
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Sheep,
- 产品应用
- ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 98kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human OXR1
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
Reactive oxygen species (ROS) are highly reactive molecules that are a normal consequence of aerobic metabolism. Cellular ROS damage can induce apoptosis and spontaneous mutagenesis. Oxr1 (Oxidation resistance protein 1) is a 758 amino acid mitochondrial protein that is most likely involved in protection from oxidative damage. Oxr1 is highly conserved from yeast to humans and is specific to eukaryotes.Induced by heat and oxidative stress, the carboxyl-terminal half of Oxr1 is required for its function. Upregulation of superoxide dismutase and catalase was observed in developing drosophila mutants that lacked the gene encoding Oxr1, suggesting that oxidative stress may trigger compensatory protein expression. There are four isoforms of Oxr1 that are produced as a result of alternative splicing events.
Function:
May be involved in protection from oxidative damage.
Subcellular Location:
Mitochondrion.
Post-translational modifications:
Phosphorylated upon DNA damage, probably by ATM or ATR.
Similarity:
Belongs to the OXR1 family.
Contains 1 GRAM domain.
Contains 1 LysM repeat.
Contains 1 TLD domain.
Database links:Entrez Gene: 55074Human
Entrez Gene: 170719Mouse
Entrez Gene: 117520Rat
Omim: 605609Human
SwissProt: Q8N573Human
SwissProt: Q4KMM3Mouse
SwissProt: Q4V8B0Rat
Unigene: 127286Human
Unigene: 740427Human
Unigene: 254267Mouse
Unigene: 4252Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.