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货号： bs-17540R-RBITC 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-17540R-RBITC
- 英文名称
- Anti-HLA DOB/RBITC
- 中文名称
- 罗丹明（RBITC）标记的组织相容性抗原DOB抗体
- 别 名
- DO beta chain; DOB; DOB_HUMAN; HLA class II histocompatibility antigen; HLA class II histocompatibility antigen DO beta chain; HLA-DOB; Major histocompatibility complex class II DO beta; Major histocompatibility complex class II DO beta chain; MHC class II antigen DOB.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 细胞生物 免疫学
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human,
- 产品应用
- ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 28kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human HLA DOB
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
HLA-DOB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DOA) and a beta chain (DOB), both anchored in the membrane. It is located in intracellular vesicles. DO suppresses peptide loading of MHC class II molecules by inhibiting HLA-DM. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. [provided by RefSeq, Jul 2008]
Function:
Important modulator in the HLA class II restricted antigen presentation pathway by interaction with the HLA-DM molecule in B cells. Modifies peptide exchange activity of HLA-DM.
Subcellular Location:
Endosome membrane. Lysosome membrane. Complexes with HLA-DM molecule during intracellular transport and in endosomal/lysosomal compartments. Heterotetramerization is necessary to exit the ER.
Similarity:
Belongs to the MHC class II family.
Contains 1 Ig-like C1-type (immunoglobulin-like) domain.
Database links:Entrez Gene: 607786Dog
Entrez Gene: 3112Human
Omim: 600629Human
SwissProt: P13765Human
Unigene: 1802Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.