产品中心
当前位置:首页>产品中心Anti-SEPT12/RBITC
货号: bs-7771R-RBITC 基本售价: 2980.0 元 规格: 100ul
产品信息
- 产品编号
- bs-7771R-RBITC
- 英文名称
- Anti-SEPT12/RBITC
- 中文名称
- 罗丹明(RBITC)标记的细胞分化蛋白SEPT12抗体
- 别 名
- SEPT12; SEPT 12; SEP12_HUMAN; Septin-12; Septin 12; Septin12.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 细胞生物 细胞周期蛋白 细胞分化 细胞骨架
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Sheep, Zebrafish
- 产品应用
- IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 41kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human SEPT12
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis.
Function:
Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential).
Subunit:
Septins polymerize into heterooligomeric protein complexes that form filaments, and can associate with cellular membranes, actin filaments and microtubules. GTPase activity is required for filament formation (By similarity). Interacts with SEPT6 and SEPT11. Forms homodimers.
Subcellular Location:
Cytoplasm. Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, spindle. Cell projection, cilium, flagellum. Note=At interphase, forms a filamentous structure in the cytoplasm. During anaphase, translocates to the central spindle region and to the midbody during cytokinesis. Found in the sperm annulus.
Tissue Specificity:
Widely expressed.
DISEASE:
Defects in SEPT12 are the cause of spermatogenic failure 10 (SPGF10) [MIM:614822]. An infertility disorder caused by spermatogenesis defects. It results in decreased sperm motility, concentration, and multiple sperm structural defects. The most prominent feature is a defective sperm annulus, a ring structure that demarcates the midpiece and the principal piece of the sperm tail.
Similarity:
Belongs to the septin family.
Database links:Entrez Gene: 124404 Human
Entrez Gene: 71089 Mouse
Entrez Gene: 363542 Rat
Omim: 611562 Human
SwissProt: Q8IYM1 Human
SwissProt: Q4V8G5 Rat
Unigene: 126780 Human
Unigene: 123511 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
SEPTIN(SEPT)家族是细胞骨架蛋白的一种,具有GTPase的活性。经研究发現,SEPT参与细胞核分裂、细胞膜的运输以及构成细胞骨架。