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货号： bs-8044R-RBITC 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-8044R-RBITC
- 英文名称
- Anti-KBTBD10/RBITC
- 中文名称
- 罗丹明（RBITC）标记的BTB-kelch蛋白家族10抗体
- 别 名
- cb52; fb24f05; fc15e07; Gm112; KBTBD10; Kel like protein 23; Kelch related protein 1; KRP1; MGC143407; Sarcosin; sbcb52; wufb24f05; wufc15e07; KBTBA_HUMAN.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 心血管 细胞生物 发育生物学 信号转导 细胞凋亡 转录调节因子 细胞骨架
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep,
- 产品应用
- IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 68kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human KBTBD10
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
Sarcosin contains 1 BTB (POZ) domain and is required for pseudopod elongation in transformed cells. Sarcosin mRNA is up-regulated by less than two folds in the heart in human patients with HCM.
Function:
Required for pseudopod elongation in transformed cells. Substrate-specific adapter of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
Subunit:
Interacts with NRAP (By similarity). Part of a complex that contains CUL3, RBX1 and KBTBD10.
Subcellular Location:
Cytoplasm. Cytoplasm, cytoskeleton. Cell projection, pseudopodium. Cell projection, ruffle. Note=Predominantly cytoplasmic but can co-localize with F-actin at the membrane ruffle-like structures at the tips of transformation-specific pseudopodia.
Post-translational modifications:
Ubiquitinated and probably targeted for proteasome-independent degradation.
Similarity:
Contains 1 BTB (POZ) domain.
Contains 5 Kelch repeats.
Database links:
UniProtKB/Swiss-Prot: O60662.2
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.