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货号： bs-6939R-RBITC 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-6939R-RBITC
- 英文名称
- Anti-Beta-synuclein/RBITC
- 中文名称
- 罗丹明（RBITC）标记的核突触蛋白β/β synuclein抗体
- 别 名
- beta Synuclein; Phosphoneuroprotein 14; Beta-synuclein; PNP14; SNCB; Synuclein beta; SYUB_HUMAN.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 细胞生物 免疫学 神经生物学 细胞类型标志物
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Dog, Pig, Cow, Rabbit,
- 产品应用
- IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 15kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human beta Synuclein
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
The protein encoded by this gene is highly homologous to alpha-synuclein. These proteins are abundantly expressed in the brain and putatively inhibit phospholipase D2 selectively. The encoded protein, which may play a role in neuronal plasticity, is abundant in neurofibrillary lesions of patients with Alzheimer disease. This protein has been shown to be highly expressed in the substantia nigra of the brain, a region of neuronal degeneration in patients with Parkinson disease; however, no direct relation to Parkinson disease has been established. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008].
Function:
Non-amyloid component of senile plaques found in Alzheimer disease. Could act as a regulator of SNCA aggregation process. Protects neurons from staurosporine and 6-hydroxy dopamine (6OHDA)-stimulated caspase activation in a p53/TP53-dependent manner. Contributes to restore the SNCA anti-apoptotic function abolished by 6OHDA. Not found in the Lewy bodies associated with Parkinson disease.
Subcellular Location:
Cytoplasm.
Tissue Specificity:
Expressed predominantly in brain; concentrated in presynaptic nerve terminals.
Similarity:
Belongs to the synuclein family.
Database links:Entrez Gene: 6620 Human
Entrez Gene: 104069 Mouse
Entrez Gene: 113893 Rat
Omim: 602569 Human
SwissProt: Q16143 Human
SwissProt: Q91ZZ3 Mouse
SwissProt: Q63754 Rat
Unigene: 90297 Human
Unigene: 200843 Mouse
Unigene: 20352 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.