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货号： bs-11323R-RBITC 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-11323R-RBITC
- 英文名称
- Anti-Neuroglycan C/RBITC
- 中文名称
- 罗丹明（RBITC）标记的跨膜硫酸软骨素蛋白聚糖C抗体
- 别 名
- Acidic leucine rich EGF like domain containing brain protein; Acidic leucine-rich EGF-like domain-containing brain protein; Caleb; CSPG5_HUMAN.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 细胞生物 神经生物学 干细胞 细胞类型标志物
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Dog, Pig, Cow, Sheep,
- 产品应用
- ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 57kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human Neuroglycan C
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
Neuroglycan C is a brain-specific chondroitin sulfate proteoglycan (CSPG) implicated in the proliferation of neural stem and progenitor cells. Neuro-glycan C is a single-pass membrane protein that can manifest as a part-time proteoglycan depending on the tissue expressing it. In its proteoglycan form, Neuroglycan C exhibits chondroitin sulfate glycans and functions as a receptor for midkine, a growth factor that binds heparin, to affect cytoskeletal changes. By means of ectodomain shedding, the ectodomain of Neuroglycan C is able to enhance neurite outgrowth from neurons. Neurite growth stimulation is affected by both an EGF-like and an acidic amino acid domain found on the shed ectodomain. Both domains instigate neurite growth, however, these domains exhibit differing functionality as to number of neurites produced and neuron types stimulated.
Function:
May function as a growth and differentiation factor involved in neuritogenesis. May induce ERBB3 activation.
Subunit:
Binds TNR and probably TNC (By similarity). Interacts with ERBB3 and GOPC.
Subcellular Location:
Cell membrane. Endoplasmic reticulum membrane. Golgi apparatus membrane. In neurons, localizes to synaptic junctions (By similarity). Also detected in the endoplasmic reticulum and the Golgi (By similarity). Partially enriched in lipid rafts.
Tissue Specificity:
Restricted to brain (at protein level).
Post-translational modifications:
O-glycosylated; contains chondroitin sulfate glycans. Part-time proteoglycan, expressed in part as a proteoglycan exhibiting chondroitin sulfate glycans and in part as a non-proteoglycan form. The relative amount of both forms depends on tissues and tissues maturation.
Phosphorylated; in intracellular and extracellular parts.
Similarity:
Contains 1 EGF-like domain.
Database links:Entrez Gene: 10675 Human
Entrez Gene: 29873 Mouse
Entrez Gene: 50568 Rat
Omim: 606775 Human
SwissProt: O95196 Human
SwissProt: Q49AA8 Human
SwissProt: Q71M36 Mouse
SwissProt: Q9ERQ6 Rat
Unigene: 45127 Human
Unigene: 38496 Mouse
Unigene: 10146 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.