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货号： bs-11408R-RBITC 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-11408R-RBITC
- 英文名称
- Anti-ACTHR/RBITC
- 中文名称
- 罗丹明（RBITC）标记的促肾上腺皮质激素受体
- 别 名
- ACTH receptor; ACTH-R; ACTHR; ACTHR_HUMAN; Adrenocorticotropic hormone receptor; Adrenocorticotropin receptor; Corticotropin receptor; MC2 receptor; MC2-R; MC2R; Melanocortin 2 receptor (adrenocorticotropic hormone); Melanocortin 2 receptor; Melanocortin receptor 2.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 肿瘤 心血管 细胞生物 神经生物学 信号转导 G蛋白偶联受体 G蛋白信号
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Dog,
- 产品应用
- ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 34kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human MC2 receptor (67-105aa)
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
MC2R encodes one member of the five-member G-protein associated melanocortin receptor family. Melanocortins (melanocyte-stimulating hormones and adrenocorticotropic hormone) are peptides derived from pro-opiomelanocortin (POMC). MC2R is selectively activated by adrenocorticotropic hormone, whereas the other four melanocortin receptors recognize a variety of melanocortin ligands. Mutations in MC2R can result in familial glucocorticoid deficiency.
Function:
Receptor for ACTH. This receptor is mediated by G proteins (G(s)) which activate adenylate cyclase.
Subunit:
Interacts with FALP/MRAP.
Subcellular Location:
Cell membrane; Multi-pass membrane protein.
Tissue Specificity:
Melanocytes and corticoadrenal tissue.
DISEASE:
Defects in MC2R are the cause of glucocorticoid deficiency type 1 (GCCD1) [MIM:202200]; also known as familial glucocorticoid deficiency type 1 (FGD1). GCCD1 is an autosomal recessive disorder due to congenital insensitivity or resistance to adrenocorticotropin (ACTH). It is characterized by progressive primary adrenal insufficiency, without mineralocorticoid deficiency.
Similarity:
Belongs to the G-protein coupled receptor 1 family.
Database links:Entrez Gene: 483980Dog
Entrez Gene: 4158Human
Entrez Gene: 17200Mouse
Entrez Gene: 282839Rat
Omim: 607397Human
SwissProt: Q01718Human
SwissProt: Q64326Mouse
Unigene: 248144Human
Unigene: 426053Mouse
Unigene: 92460Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.