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货号： bs-11781R-RBITC 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-11781R-RBITC
- 英文名称
- Anti-IF3/RBITC
- 中文名称
- 罗丹明（RBITC）标记的线粒体翻译起始因子3抗体
- 别 名
- Mitocondrial Translational Initiation Factor 3; DC38; IF 3; IF 3Mt; IF-3(Mt); IF-3Mt; IF3; IF3(mt); IF3M_HUMAN; IF3Mt; mitochondrial; Mt; MTIF3; Translation initiation factor IF 3, mitochondrial precursor; Translation initiation factor IF-3.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 细胞生物 神经生物学 表观遗传学 Alzheimers
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human,
- 产品应用
- ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 28kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human Mitocondrial Translational Initiation Factor 3
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
IF3 is also known as MTIF3 (mitochondrial translational initiation factor 3), DC38, IF3(mt) or IF-3mt, and is a 278 amino acid protein that is localized to mitochondria. IF3 aids in the initiation of protein synthesis by binding the 28S ribosomal subunit, which is a protein synthesis initiation site. The 28S and 39S ribosomal structures are subunits of the 55S ribosome, whose formation is favored in the absence of IF3, because IF3 allows the subunits to remain in their free form. Altered forms of IF3 may affect IF3’s function, which could alter the availability of mitochondrial encoded proteins, leading to oxidative stress and possibly causing an increased susceptibility to Parkinson’s disease. Polymorphism of the gene encoding IF3 is thought to be associated with Parkinson’s disease.
Function:
IF-3 binds to the 28S ribosomal subunit and shifts the equilibrum between 55S ribosomes and their 39S and 28S subunits in favor of the free subunits, thus enhancing the availability of 28S subunits on which protein synthesis initiation begins.
Subcellular Location:
Mitochondrion.
Similarity:
Belongs to the IF-3 family.
Database links:Entrez Gene: 219402Human
SwissProt: Q9H2K0Human
Unigene: 534582Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.