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HRPBiotinGoldRBITCAPFITCCy3Cy5Cy5.5Cy7PEPE-Cy3PE-Cy5PE-Cy5.5PE-Cy7APCAlexa Fluor 350Alexa Fluor 488Alexa Fluor 555Alexa Fluor 594Alexa Fluor 647

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Anti-BCL-6/Gold

货号: bsm-51096M-Gold 基本售价: 2980.0 元 规格: 100ul

产品信息

产品编号
bsm-51096M-Gold
英文名称
Anti-BCL-6/Gold
中文名称
胶体金标记的小鼠抗Bcl-6单克隆抗体
别    名
B-Cell CLL/Lymphoma 6; Zinc Finger Protein 51; Zinc Finger And BTB Domain-Containing Protein 27; B-Cell Lymphoma 5 Protein; Protein LAZ-3; ZBTB27; ZNF51; BCL-5; BCL-6; BCL5; LAZ3; Lymphoma-Associated Zinc Finger Gene On Chromosome 3; Cys-His2 Zinc Finger Transcription Factor; Zinc Finger Transcription Factor BCL6S; B-Cell Lymphoma 6 Protein Transcript; B-Cell Lymphoma 6 Protein; BCL6A; BCL6_HUMAN;   
规格价格
100ul/2980元购买        大包装/询价
说 明 书
100ul(10nm  15nm  35nm
研究领域
肿瘤  免疫学  信号转导  细胞凋亡  转录调节因子  
抗体来源
Mouse
克隆类型
Monoclonal
克 隆 号
6F5
交叉反应
Human, 
产品应用
IEM=1:20-200 IGS=1:20-200 GICA=1:20-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量
78kDa
性    状
Lyophilized or Liquid
浓    度
0.4mg/1ml
免 疫 原
KLH conjugated synthetic peptide derived from human BCL-6
亚    型
IgG1
纯化方法
affinity purified by Protein G
储 存 液
Constituents: 0.02M TBS, pH 8.2 with 10mg/ml BSA and 0.05% NaN3, 50% glycerol. Or Lyophilized. Buffer = 0.02M TBS, pH 8.2 with 10mg/ml BSA and 0.05% NaN3. Reconstitute with sterile distilled water.
保存条件
Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍
background:
The protein encoded by this gene is a zinc finger transcription factor and contains an N-terminal POZ domain. This protein acts as a sequence-specific repressor of transcription, and has been shown to modulate the transcription of STAT-dependent IL-4 responses of B cells. This protein can interact with a variety of POZ-containing proteins that function as transcription corepressors. This gene is found to be frequently translocated and hypermutated in diffuse large-cell lymphoma (DLCL), and may be involved in the pathogenesis of DLCL. Alternatively spliced transcript variants encoding different protein isoforms have been found for this gene. [provided by RefSeq, Aug 2015]

Function:
Transcriptional repressor mainly required for germinal center (GC) formation and antibody affinity maturation which has different mechanisms of action specific to the lineage and biological functions. Forms complexes with different corepressors and histone deacetylases to repress the transcriptional expression of different subsets of target genes. Represses its target genes by binding directly to the DNA sequence 5-TTCCTAGAA-3 (BCL6-binding site) or indirectly by repressing the transcriptional activity of transcription factors. In GC B-cells, represses genes that function in differentiation, inflammation, apoptosis and cell cycle control, also autoregulates its transcriptional expression and up-regulates, indirectly, the expression of some genes important for GC reactions, such as AICDA, through the repression of microRNAs expression, like miR155. An important function is to allow GC B-cells to proliferate very rapidly in response to T-cell dependent antigens and tolerate the physiological DNA breaks required for immunglobulin class switch recombination and somatic hypermutation without inducing a p53/TP53-dependent apoptotic response. In follicular helper CD4(+) T-cells (T(FH) cells), promotes the expression of T(FH)-related genes but inhibits the differentiation of T(H)1, T(H)2 and T(H)17 cells. Also required for the establishment and maintenance of immunological memory for both T- and B-cells. Suppresses macrophage proliferation through competition with STAT5 for STAT-binding motifs binding on certain target genes, such as CCL2 and CCND2. In response to genotoxic stress, controls cell cycle arrest in GC B-cells in both p53/TP53-dependedent and -independent manners. Besides, also controls neurogenesis through the alteration of the composition of NOTCH-dependent transcriptional complexes at selective NOTCH targets, such as HES5, including the recruitment of the deacetylase SIRT1 and resulting in an epigenetic silencing leading to neuronal differentiation.

Subunit:
Homodimer. Interacts (via BTB domain) with the corepressors BCOR, NCOR1 and SMRT/NCOR2; the interactions are direct. Forms preferably ternary complexes with BCOR and SMRT/NCOR2 on target gene promoters but, on enhancer elements, interacts with SMRT/NCOR2 and HDAC3 to repress proximal gene expression. Interacts with histone deacetylases HDAC2, HDAC5 and HDAC9 (via the catalytic domain). Interacts with ZBTB7 and BCL6B. Interacts with SCF(FBXO11) complex; the interaction is independent of phosphorylation and promotes ubiquitination. Interacts (when phosphorylated) with PIN1; the interaction is required for BCL6 degradation upon genotoxic stress. Interacts with ZBTB17; inhibits ZBTB17 transcriptional activity. Interacts with CTBP1, autoinhibits its transcriptional expression. Interacts with NOTCH1 NCID and SIRT1; leads to a epigenetic repression of selective NOTCH1-target genes. Interacts (nor via BTB domain neither acetylated) with the NuRD complex components CHD4, HDAC1, MBD3 and MTA3; the interaction with MTA3 inhibits BCL6 acetylation and is required for BCL6 transpriptional repression.

Subcellular Location:
Nucleus

Tissue Specificity:
Expressed in germinal center T- and B-cells and in primary immature dendritic cells.

Post-translational modifications:
Phosphorylated by MAPK1 in response to antigen receptor activation at Ser-333 and Ser-343. Phosphorylated by ATM in response to genotoxic stress. Phosphorylation induces its degradation by ubiquitin/proteasome pathway.
Polyubiquitinated. Polyubiquitinated by SCF(FBXO11), leading to its degradation by the proteasome.
Acetylated at Lys-379 by EP300 which inhibits the interaction with NuRD complex and the transcriptional repressor function. Deacetylated by HDAC- and SIR2-dependent pathways.

Database links:

Entrez Gene: 604 Human

Entrez Gene: 12053 Mouse

Entrez Gene: 303836 Rat

Omim: 109565 Human

SwissProt: P41182 Human

SwissProt: P41183 Mouse

Unigene: 478588 Human

Unigene: 347398 Mouse

Unigene: 20571 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.