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货号： bs-2816R-Gold 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-2816R-Gold
- 英文名称
- Anti-Claudin 3, 4, 6, 9/Gold
- 中文名称
- 胶体金标记的紧密连接蛋白3, 4, 6, 9抗体
- 别 名
- pan-Claudin; Claudin 3 + 4 + 6 + 9; C7orf1; Claudin3; Claudin-3; CLDN 3; CLDN3; Clostridium perfringens enterotoxin receptor 2; CPE R2; CPE receptor 2; CPETR 2; CPETR2; HRVP 1; HRVP1; Rat ventral prostate 1 like protein; CLD3_HUMAN; CLD4_HUMAN; CLD6_HUMAN; CLD9_HUMAN; CPE-receptor 2; Rat ventral prostate.1 protein homolog; RVP 1; RVP1; Ventral prostate.1 like protein; Ventral prostate.1 protein homolog.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul（10nm 15nm 35nm）
- 研究领域
- 肿瘤 信号转导 转录调节因子 细胞粘附分子
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Dog, Pig, Cow, Sheep,
- 产品应用
- IEM=1:20-200 IGS=1:20-200 GICA=1:20-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 23kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 0.4mg/1ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human Claudin 3, 4, 6, 9
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- Constituents: 0.02M TBS, pH 8.2 with 10mg/ml BSA and 0.05% NaN3, 50% glycerol. Or Lyophilized. Buffer = 0.02M TBS, pH 8.2 with 10mg/ml BSA and 0.05% NaN3. Reconstitute with sterile distilled water.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. The protein encoded by this intronless gene, a member of the claudin family, is an integral membrane protein and a component of tight junction strands. It is also a low-affinity receptor for Clostridium perfringens enterotoxin, and shares aa sequence similarity with a putative apoptosis-related protein found in rat. [provided by RefSeq, Jul 2008]
Function:
Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
Subunit:
Directly interacts with TJP1/ZO-1, TJP2/ZO-2 and TJP3/ZO-3.
Subcellular Location:
Cell junction, tight junction. Cell membrane; Multi-pass membrane protein.
DISEASE:
Note=CLDN3 is located in the Williams-Beuren syndrome (WBS) critical region. WBS results from a hemizygous deletion of several genes on chromosome 7q11.23, thought to arise as a consequence of unequal crossing over between highly homologous low-copy repeat sequences flanking the deleted region.
Similarity:
Belongs to the claudin family.
Database links:Entrez Gene: 1365Human
Entrez Gene: 12739Mouse
Entrez Gene: 65130Rat
Omim: 602910Human
SwissProt: O15551Human
SwissProt: Q9Z0G9Mouse
SwissProt: Q63400Rat
Unigene: 647023Human
Unigene: 158662Mouse
Unigene: 4513Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.