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货号： bs-20107R-Gold 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-20107R-Gold
- 英文名称
- Anti-HPV18 E4/Gold
- 中文名称
- 胶体金标记的人乳头瘤病毒18型E4抗体
- 别 名
- HPV18 E4 protein; HPV 18 E4 protein; Human Papilloma Virus; Human papillomavirus type 18 E4; Human papillomavirus type 18 E4; Protein E4; Human Papillomavirus 18 (E4); HPV18 E4; E4 protein (HPV18); VE4_HPV18; HPV18-E4.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul（10nm 15nm 35nm）
- 研究领域
- 肿瘤
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- HPV18
- 产品应用
- IEM=1:20-200 IGS=1:20-200 GICA=1:20-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 10kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 0.4mg/1ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from HPV18 E4 protein HPV18 E4
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.02M TBS(pH8.2) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
The two primary oncoproteins of high risk HPV types are E6 and E7. The “E” designation indicates that these two proteins are expressed early in the HPV life cycle, while the "L" designation indicates late expression. The HPV genome is composed of six early (E1, E2, E4, E5, E6, and E7) ORFs, two late (L1 and L2) ORFs, and a non-coding long control region (LCR). After the host cell is infected viral early promoter is activated and a polycistronic primary RNA containing all six early ORFs is transcribed. This polycistronic RNA then undergoes active RNA splicing to generate multiple isoforms of mRNAs. One of the spliced isoform RNAs, E6*I, serves as an E7 mRNA to translate E7 protein. However, viral early transcription subjects to viral E2 regulation and high E2 levels repress the transcription. HPV genomes integrate into host genome by disruption of E2 ORF, preventing E2 repression on E6 and E7. Thus, viral genome integration into host DNA genome increases E6 and E7 expression to promote cellular proliferation and the chance of malignancy. The degree to which E6 and E7 are expressed is correlated with the type of cervical lesion that can ultimately develop.
Similarity:
Belongs to the papillomaviridae E4 protein family.
Database links:UniProtKB: locus VE4_HPV18, accession P06791
GeneID:1489086
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.