Quantikine Immunoassay Control Set 736 for Human Dkk-1 (1 EA)
货号：
QC76 基本售价：
1774.7 元 规格：
1 Each
产品信息
概述| 货号 | QC76 |
| 简介 | For use with catalog number DKK100 |
| 别名 | dickkopf (Xenopus laevis) homolog 1; dickkopf homolog 1 (Xenopus laevis); dickkopf related protein-1; Dickkopf-1; dickkopf-related protein 1; DKK-1; hDkk-1; SKdickkopf-1 like |
全称 | Dickkopf-1 |
性能| 供应商 | R&D Systems |
| Entrez Gene IDs | 22943 (Human); 13380 (Mouse) |
| 背景 | Members of the dickkopf-related protein family (Dkk-1, -2, -3, and -4) are secreted proteins with two cysteine-rich domains separated by a linker region. Dkk-3 and -4 also have one prokineticin domain. Dkk-1, -2, and -4 function as antagonists of canonical Wnt signaling by binding to LRP5/6, preventing interaction of LRP5/6 with Wnt-Frizzled complexes. Dkk-1, -2, and -4 also bind cell surface Kremen-1 or -2 and promote the internalization of LRP5/6. Antagonistic activity of Dkk-3 has not been demonstrated. Dkk proteins have distinct patterns of expression in adult and embryonic tissues and have a wide range of effects on tissue development and morphogenesis. The Dkk family also includes Soggy, which is homologous to Dkk-3 but not to the other family members. Soggy has not been shown to inhibit Wnt signaling, and its role in the pathway is unclear. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 参考文献 | - Cancer Biomarkers
- Dkk-1: Upsetting the Balance in Rheumatoid Arthritis
- ICC / IHC Images: Dkk-1
- Mini-review: DNA Damage Response
- Mini-review: Wnt Receptors & Pathways
- Negative Regulators of EMT
- New Tools: for Developmental Research
- Technical Notes: Wnt Inhibitor Activity
- Wnt Family
- Wnt Inhibitors
- Wnt: A polarizing factor in early mouse development
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