概述| 货号 | QC218 |
| 简介 | For use with catalog number DBNT00 |
| 别名 | Abrineurin; ANON2; brain-derived neurotrophic factor; BULN2; MGC34632; neurotrophin |
全称 | Brain-derived Neurotrophic Factor |
性能| 供应商 | R&D Systems |
| Entrez Gene IDs | 627 (Human); 12064 (Mouse); 24225 (Rat) |
| 背景 | BDNF (Brain-Derived Neurotrophic Factor) is a secreted protein that regulates many aspects of neuronal development and function in the nervous system. It is produced as proBDNF in response to neuronal activity or inflammatory stimulation and is then cleaved before associating into a homodimer. It is expressed throughout the nervous system as well as by fibroblasts, megakaryocytes/platelets, and smooth muscle cells. BDNF regulates neural stem cell survival and differentiation, axon/dendrite differentiation, synapse formation and maturation, and refinement of developing circuits. It is also a key regulator of synaptic plasticity and late-phase long-term potentiation. BDNF signals through the TrkB and NGF R/TNFRSF16 receptors. Secreted proBDNF can bind to NGF R/TNFRSF16 and induce long-term depression and cell apoptosis. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 参考文献 | - Adult Neurogenesis
- Developmental Factors Implicated in Neurodegeneration
- Diabetes
- Diabetic Peripheral Neuropathy
- ICC / IHC Images: BDNF
- Mini-review: Neurotrophic Factors
- Neurotrophic Factors and Receptors
- Neurotrophin/Trk Family
- Obesity
- Synaptic BDNF: Connecting Physiology to Therapy
- TrkB Integrates Neural Precursor Cell Migration & Differentiation in the Developing Brain
- VPS10P-domain Family
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